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Micrornas As Potential Diagnostic, Prognostic, and Predictive Biomarkers for Acute Graft-Versus-Host Disease Publisher Pubmed



Motaei J1, 2 ; Yaghmaie M3 ; Ahmadvand M3 ; Pashaiefar H3 ; Kerachian MA1, 2, 4
Authors
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Authors Affiliations
  1. 1. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cancer Genetics Research Unit, Reza Radiotherapy and Oncology Center, Mashhad, Iran

Source: Biology of Blood and Marrow Transplantation Published:2019


Abstract

Successful treatment of various hematologic diseases with allogeneic hematopoietic stem cell transplantation is often limited due to the occurrence of acute graft-versus-host disease (aGVHD). So far, there are no approved molecular biomarkers for the diagnosis and prediction of aGVHD at the clinical level due to our incomplete understanding of the molecular biology of the disease. Various studies have been conducted on animal models and humans to investigate the role of microRNAs in aGVHD pathogenesis to implicate them as biomarkers and therapeutic targets. Because of their high stability, tissue specificity, ease of measurement, low cost, and simplicity, they are excellent targets for biomarkers. In this review, we focused on microRNA expression profiling studies that were performed recently in both animal models and human cases of aGVHD to identify diagnostic and predictive biomarkers for this disease. The expression pattern of microRNAs can be specific to cells and tissues. Because aGVHD affects several organs, microRNA signatures in target tissues may help to understand the molecular pathology of the disease. Identification of organ-specific microRNAs in aGVHD can be promising to categorize patients for organ-specific therapies. Thus, microRNAs can be used as noninvasive diagnostic tests in clinic to improve prophylaxis, predict incidence and severity, and reduce morbidity. © 2019 American Society for Transplantation and Cellular Therapy
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