Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effects of Vitamin D on Sexual Function and Hormones in Women With Multiple Sclerosis Publisher



Zarabadipour S1 ; Eghbali M2, 3 ; Amini L4 ; Nabavi SM5 ; Haghani H6 ; Sadeghi Avval Shahr H7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Midwifery, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nursing, School of Nursing and Midwifery, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  3. 3. Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  4. 4. Nursing and Midwifery Care Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Neurology and Cognitive Science, Research Institute of Cellular Sciences, Royan Research Center, Tehran, Iran
  6. 6. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Client-Centered Nursing Care Published:2024


Abstract

Background: Sexual dysfunction (SD) is the most common and challenging complication among women with multiple sclerosis (MS). Despite investigations into the impact of taking vitamin D on sexual function (SF), findings have not definitively recommended its use. This study aimed to evaluate the effects of vitamin D supplementation on SF and sex hormones among women with MS. Methods: This triple-blind, randomized, placebo-controlled clinical trial was conducted on 62 married women with MS and vitamin D deficiency. They were recruited from a specialized clinic for neurology in Tehran City, Iran, between August 2017 and February 2018. The subjects were randomly allocated to experimental or control groups (n=31/each group). Subjects in the experimental and control groups, respectively, received two 2000-IU vitamin D and two placebo tablets daily for 12 consecutive weeks. Serum levels of sex hormones and their SF were evaluated before and after the intervention. The SF assessment was performed using the female SF index. The obtained data were analyzed using an independent samples t-test, paired t-test, Fisher exact test, Mann-Whitney U test, and the chi-square test in SPSS software, version 22. The significance level was determined at <0.05. Results: The findings revealed no significant difference between the two groups regarding sex hormones, Vitamin D, and SF levels before the intervention. The study results indicated that taking vitamin D supplementation for 12 weeks significantly impacts the improvement of SF and sex hormones (P<0.05). Conclusion: Twelve weeks’ consumption of vitamin D supplementation may improve SF and sex hormones among women with MS. Copyright © 2024 The Author(s)
Related Docs
View other Related Docs
1. Depression, Sexual Function and Sexual Quality of Life in Iranian Women With Multiple Sclerosis (Ms), Journal of Obstetrics, Gynecology and Cancer Research (2025)
2. Aquatic Exercising May Improve Sexual Function in Females With Multiple Sclerosis – an Exploratory Study, Multiple Sclerosis and Related Disorders (2020)
3. Prevalence and Risk of Developing Sexual Dysfunction in Women With Multiple Sclerosis (Ms): A Systematic Review and Meta-Analysis, BMC Women's Health (2023)
4. The Relationship Between Postpartum Women's Sexual Function With the Type of Delivery and the Serum Concentration of Omentin-1 As a Predictive Biomarker, Iranian South Medical Journal (2023)
5. The Relationship Between Cognitive Function and Body Mass Index in Multiple Sclerosis Patients, Multiple Sclerosis and Related Disorders (2019)
6. Clinical Characteristics and Disability Progression of Early-And Late-Onset Multiple Sclerosis Compared to Adult-Onset Multiple Sclerosis, Journal of Clinical Medicine (2020)
7. Effect of Yoga on Women’S Sexual Function and Sexual Quality of Life After Vaginal Delivery, Health Education and Health Promotion (2024)
8. Cognitive Deficits in Multiple Sclerosis: Auditory and Visual Attention and Inhibitory Control, Applied Neuropsychology:Adult (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Sahraian (8)
Raziyeh Maasoumi (6)
Other Related Docs
9. Potential Efficacy of Caffeine Ingestion on Balance and Mobility in Patients With Multiple Sclerosis: Preliminary Evidence From a Single-Arm Pilot Clinical Trial, PLoS ONE (2024)
10. The Effect of the Ex-Plissit Model-Based Psychosexual Counseling on Improving Sexual Function and Sexual Quality of Life in Gynecologic Cancer Survivors: A Randomized Controlled Clinical Trial, Supportive Care in Cancer (2022)
11. Trail Making Test Could Predict Impairment in Cognitive Domains in Patients With Multiple Sclerosis: A Study of Diagnostic Accuracy, Archives of Clinical Neuropsychology (2023)
12. Sexual Function, Mental Health, and Quality of Life Under Strain of Covid-19 Pandemic in Iranian Pregnant and Lactating Women: A Comparative Cross-Sectional Study, Health and Quality of Life Outcomes (2021)
13. The Effect of Intra-Vaginal Oxytocin on Sexual Function in Breastfeeding Mothers: A Randomized Triple-Blind Placebo-Controlled Trial, BMC Pregnancy and Childbirth (2022)
14. The Effect of Practical Intimate Relationship Skills Training (Pairs) on Marital Satisfaction, Adjustment, and Sexual Function in Women Living With Hiv and Aids: A Randomized Controlled Trial, HIV and AIDS Review (2021)
15. Demographic Features, Behavioral Measures, and Clinical Factors As Predictors of Cognitive Function in Patients With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2021)
16. Recent Advances in Mesenchymal Stem Cell Therapy for Multiple Sclerosis: Clinical Applications and Challenges, Frontiers in Cell and Developmental Biology (2025)
17. The Association Between Sexual Function With Health Anxiety and Fear of Recurrence in Women With a Breast Cancer History; [با اضطراب سالمت و ترس از عود در زنان ارتباط عملکرد جنسیبررسیبقه سرطان پستانبا ساب], Iranian Journal of Breast Diseases (2023)
18. Does Significant Weight Loss After Bariatric Surgery Affect Sexual Function and Urinary Symptoms? an Iranian Study, Obesity Surgery (2023)
19. Sexual Activity, Interest and Satisfaction in Older Women in Iran, Journal of Biostatistics and Epidemiology (2019)
20. Comparative Investigation of Genital Selfimage and Sexual Function in Women With and Without a History of Female Genital Cosmetic Procedures: A Cross-Sectional Study, International Journal of Community Based Nursing and Midwifery (2024)
21. Multiple Sclerosis and Covid-19: A Retrospective Study in Iran, PLoS ONE (2023)
22. Environmental Risk Factors of Multiple Sclerosis in the Middle East and North Africa Region: A Systematic Review, Current Journal of Neurology (2021)
23. Mri Features and Disability in Multiple Sclerosis: A Systematic Review and Meta-Analysis, Journal of Neuroradiology (2024)
24. Assessment of Dysphagia and Its Associations in Patients With Secondary Progressive Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2025)
25. The Association of Serum Carnitine Levels With Severity of Fatigue in Patients With Multiple Sclerosis: A Pilot Study, Current Journal of Neurology (2023)
26. Expression Analysis of Nf-Κb-Associated Long Noncoding Rnas in Peripheral Blood Mononuclear Cells From Relapsing-Remitting Multiple Sclerosis Patients, Journal of Neuroimmunology (2021)
27. The Effect of Cognitive Behavioral Therapy on Sexual Function in Infertile Women: A Randomized Controlled Clinical Trial, Journal of Sex and Marital Therapy (2019)
28. The Effect of Psychosexual Education on Promoting Sexual Function, Genital Self-Image, and Sexual Distress Among Women With Rokitansky Syndrome: A Randomized Controlled Clinical Trial, Journal of Pediatric and Adolescent Gynecology (2022)
29. The Effect of Sexual Education Based on the Sexual Health Model on Sexual Function Among Women Living in the Suburbs: Study Protocol for a Randomized Controlled Trial, Reproductive Health (2024)
30. Women's Sexual Function During the Postpartum Period: A Systematic Review on Measurement Tools, Medicine (United States) (2024)
31. Effectiveness of Sexual Counseling Using Plissit Model to Promote Sexual Function of Women With Spinal Cord Injury: A Randomized Controlled Trial, Sexuality and Disability (2019)
32. The Effect of Mindfulness-Based Cognitive-Behavioral Sex Therapy on Improving Sexual Desire Disorder, Sexual Distress, Sexual Self-Disclosure and Sexual Function in Women: A Randomized Controlled Clinical Trial, Journal of Sex and Marital Therapy (2022)
33. The Effect of Better-Based Sex Counseling on Sexual Quality of Life in Infertile Women: A Randomized Controlled Clinical Trial, Sexuality and Disability (2022)
34. Multiple Sclerosis and Lower Urinary Tract Symptoms: A Survey of Prevalence, Characteristic and Urological Evaluations, SAGE Open Medicine (2023)
35. A Study on Sexual Functioning in Adults With Attention-Deficit/Hyperactivity Disorder, Perspectives in Psychiatric Care (2020)
36. A Study on Sexual Functioning and Depression in Iranian Women Following Cesarean Hysterectomy Due to Placental Abnormality After 3–6 Months, Women and Health (2021)
37. Protective Effects of Heat-Killed Lactobacilli Against Plasma-Induced Neurotoxicity in Multiple Sclerosis, Probiotics and Antimicrobial Proteins (2025)
38. Cognitive Deficits in Multiple Sclerosis: Auditory and Visual Attention and Inhibitory Control, Applied Neuropsychology: Adult (2025)
39. A Study on Sexual Function in Obsessive–Compulsive Disorder (Ocd) Patients With and Without Depressive Symptoms, Perspectives in Psychiatric Care (2017)
40. Covid-19 and Its Implications on the Clinico-Radiological Course of Multiple Sclerosis: A Case–Control Study; [Covid-19 Y Sus Implicaciones En El Curso Clinico-Radiologico De La Esclerosis Multiple: Un Estudio De Casos Y Controles], Medicina Clinica (2023)
41. Effects of Acupuncture on Cognitive Functions in Patients With Relapsing-Remitting Multiple Sclerosis: A Randomized Controlled Trial, Chinese Journal of Integrative Medicine (2025)
42. Effectiveness of Sexual Counseling Using Plissit Model on Sexual Function of Women With Type 2 Diabetes Mellitus: Results From a Randomized Controlled Trial, International Journal of Diabetes in Developing Countries (2019)
43. The Correlation Between Sexual Dysfunction and Intimate Partner Violence in Young Women During Pregnancy, BMC International Health and Human Rights (2020)
44. Effect of the Ex-Plissit Model on Sexual Function and Sexual Quality of Life Among Women After Hysterectomy: A Randomised Controlled Trial, Sexual Health (2019)
45. Symmetry Differences of Structural Connectivity in Multiple Sclerosis and Healthy State, Brain Research Bulletin (2023)
46. Association of Self-Reported Adherence to the Mediterranean Diet With Anthropometric Indices, Comorbidities, and Degree of Disability in Patients With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2022)
47. Comparable Efficacy and Safety of Teriflunomide Versus Dimethyl Fumarate for the Treatment of Relapsing-Remitting Multiple Sclerosis, Neurology Research International (2021)
48. The Relationship Between the Wealth Index and Pregnancy-Related Anxiety in Each Trimester of Pregnancy and Their Effect on Sexual Dysfunction, Bangladesh Journal of Medical Science (2021)
49. The Effect of Perineorrhaphy Surgery and Anterior-Posterior Vaginal Repair on Body Image, Sexual Function, and Quality of Life in Women, Tehran University Medical Journal (2022)
50. Multiple Sclerosis Projection in Tehran, Iran Using Bayesian Structural Time Series, BMC Neurology (2021)