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Matrixyl Patch Vs Matrixyl Cream: A Comparative in Vivo Investigation of Matrixyl (Mti) Effect on Wound Healing Publisher



Kachooeian M1 ; Mousivand Z2 ; Sharifikolouei E3 ; Shirangi M1 ; Firoozpour L4 ; Raoufi M2, 5 ; Sharifzadeh M6
Authors
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Authors Affiliations
  1. 1. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1416634793, Iran
  2. 2. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1416634793, Iran
  3. 3. Department of Applied Science and Technology, Politecnico di Torino (POLITO), Turin, 10129, Italy
  4. 4. Department of Medicinal Chemistry, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 1416634793, Iran
  5. 5. Physical Chemistry I, Department of Chemistry and Biology, Research Center of Micro and Nanochemistry and Engineering (Cμ), University of Siegen, Siegen, 57076, Germany
  6. 6. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1416634793, Iran

Source: ACS Omega Published:2022


Abstract

Wound healing is one of the most complex biological processes. Studies show that Matrixyl (MTI), known as a cosmetic peptide, can lead to a faster healing process. The contribution of MTI to collagen formation during wound healing also depends on its mode of delivery and its release over time. Here, we investigate two modes of MTI-delivery system, the influence of MTI patch for wound healing application in comparison with MTI cream. In this study, animals were randomly divided into seven groups and studied for 21 days: patches containing two different concentrations of MTI (P-MTI-0.1 mg and P-MTI-1 mg), a cream containing MTI (C-MTI-1 mg), a patch (P-MTI-0), a cream with no MTI (C-MTI-0), a positive control (Comfeel), and a negative control (sham) group. To study the wound healing process, the change in collagen density, angiogenesis, epitheliogenesis, histopathology, immunohistochemical analysis, and wound area through imaging was monitored and measured. The macroscopic results showed that wound healing was improved from 63.5 up to 81.81% in treatment groups compared to that in the negative control group (P < 0.05 and P < 0.001). In addition, C-MTI-1 and P-MTI-1 had a larger impact on wound healing compared to that in the positive control group (Comfeel, P < 0.05). In hematoxylin and eosin (H&E) staining analysis, the rejuvenation of skin appendage was visible in both groups of cream and patches with MTI. According to the obtained results, the re-epithelialization had a higher range for the patch with MTI in comparison with cream containing MTI and positive control. © 2022 The Authors. Published by American Chemical Society.
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