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In Vitro and in Vivo Evaluation of Porous Alginate Hydrogel Containing Retinoic Acid for Skin Wound Healing Applications Publisher



Nazarnezhad S1 ; Salehi M2, 3, 4 ; Samadian H5 ; Ehtermi A6 ; Kasaiyan N7 ; Khastar H4 ; Abbaszadehgoudarzi G8 ; Kolarijani NR9 ; Yeganehfard H10 ; Ziaei H10
Authors
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Authors Affiliations
  1. 1. Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  4. 4. Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  5. 5. Dental Implants Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  7. 7. Science and Research Branch of, Islamic Azad University, Tehran, Iran
  8. 8. Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  9. 9. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  10. 10. Dentistry Faculty, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Bioactive and Compatible Polymers Published:2022


Abstract

The current study’s main aim was to fabricate and evaluate alginate (Alg) hydrogel containing retinoic acid (RA) as wound healing materials. Different RA concentrations (2, 10, and 50% w/w) were incorporated into the hydrogel. The results showed that the prepared hydrogels had a porous structure with a pore size of 69.69 ± 22.1 µm for pure Alg hydrogel and 78.44 ± 27.8 µm for Alg/RA hydrogel. The swelling measurement showed that the hydrogels swelled up to 65% and the incorporation of RA reduced the degree of swelling. The in vitro studies confirmed the hemo- and biocompatibility of the Alg/RA 2% and increasing the RA concentration induced hemolysis and toxic effects. The animal studies showed that the lowest RA concentration resulted in the best treatment outcome while increasing the RA concentration suppressed the healing process. In conclusion, these results showed that RA induced wound healing process at low concentration, and the prepared hydrogel could be used as the wound healing materials. © The Author(s) 2022.
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