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Colon Cancer Targeting Using Conjugates Biomaterial 5-Flurouracil Publisher Pubmed



Jaferian S1 ; Negahdari B2 ; Eatemadi A2, 3
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
  2. 2. Department of Medical Biotechnology, School of Advance Science in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Lorestan, Iran

Source: Biomedicine and Pharmacotherapy Published:2016


Abstract

There has been several research works on the development of an oral delivery system to deliver cytotoxic and chemo preventive agents directly at the targeted site of action with reduced unwanted side effects. The efficacy of the site-specific delivery system of a drug to colon has been proven to increase the drugs concentration at the target site, and thus requires a reduced dose of the drug with minimized side effects. This review includes discussion of the delivery systems of 5-FU using biodegradable materials and some significant outcomes in the pre-clinical development of 5-fluorouracil carriers for the colon cancer. © 2016 Elsevier Masson SAS
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