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Recent Advances in Cardiac Regeneration: Stem Cell, Biomaterial and Growth Factors Publisher Pubmed



Cheraghi M1 ; Namdari M1 ; Negahdari B2 ; Eatemadi A2, 3, 4
Authors
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Authors Affiliations
  1. 1. Department of Cardiology, Lorestan University of Medical Sciences, Khoramabad, Iran
  2. 2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Razi Herbal Medicine Research Center, Lorestan University of Medical Science, Khorramabad, Iran
  4. 4. Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Lorestan, Iran

Source: Biomedicine and Pharmacotherapy Published:2017


Abstract

Myocardial infarction has been reported to be responsible for about 7.3 million deaths each year globally. Present treatments for myocardial infarction have been more palliative rather than curative. Over the past few years, stem cells have demonstrated its potency in regenerating damaged cardiac tissue, especially after myocardial infarction. However, limited short half-life of the protein and cell therapy and low transplanted cell survival rate as demonstrated via several clinical trials have lead to development of more potent and novel delivery systems like biomaterial delivery system and the use of various growth factors. In this review, we will be enumerating and discussing the recent advances in cardiac regeneration with focus on stem cell, biomaterial and growth factors. © 2016 Elsevier Masson SAS
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