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Unveiling the Molecular Landscape of Pancreatic Ductal Adenocarcinoma: Insights Into the Role of the Compass-Like Complex Publisher Pubmed



Jamali M1 ; Barar E2 ; Shi J1
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Authors Affiliations
  1. 1. Department of Pathology & Clinical Labs, Rogel Cancer Center, University of Michigan, Ann Arbor, 48109, MI, United States
  2. 2. Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, 1416634793, Iran

Source: International Journal of Molecular Sciences Published:2024


Abstract

Pancreatic ductal adenocarcinoma (PDAC) is poised to become the second leading cause of cancer-related death by 2030, necessitating innovative therapeutic strategies. Genetic and epigenetic alterations, including those involving the COMPASS-like complex genes, have emerged as critical drivers of PDAC progression. This review explores the genetic and epigenetic landscape of PDAC, focusing on the role of the COMPASS-like complex in regulating chromatin accessibility and gene expression. Specifically, we delve into the functions of key components such as KDM6A, KMT2D, KMT2C, KMT2A, and KMT2B, highlighting their significance as potential therapeutic targets. Furthermore, we discuss the implications of these findings for developing novel treatment modalities for PDAC. © 2024 by the authors.
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