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Emerging Role of Enhancer Rnas As Potential Diagnostic and Prognostic Biomarkers in Cancer Publisher



Panahimoghadam S1, 2 ; Hassani S3, 4 ; Farivar S2 ; Vakhshiteh F5
Authors
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Authors Affiliations
  1. 1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 1411713116, Iran
  2. 2. Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, 1983969411, Iran
  3. 3. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  4. 4. Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, 1417614411, Iran
  5. 5. Oncopathology Research Center, Iran University of Medical Sciences (IUMS), Tehran, 1449614535, Iran

Source: Non-coding RNA Published:2022


Abstract

Enhancers are distal cis-acting elements that are commonly recognized to regulate gene expression via cooperation with promoters. Along with regulating gene expression, enhancers can be transcribed and generate a class of non-coding RNAs called enhancer RNAs (eRNAs). The current discovery of abundant tissue-specific transcription of enhancers in various diseases such as cancers raises questions about the potential role of eRNAs in disease diagnosis and therapy. This review aimed to demonstrate the current understanding of eRNAs in cancer research with a focus on the potential roles of eRNAs as prognostic and diagnostic biomarkers in cancers. © 2022 by the authors.
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