Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death?

Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death? Publisher

Barar E¹ ; Shi J²

Show Affiliations

1. Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
2. Department of Pathology & Clinical Labs, Rogel Cancer Center, Center for RNA Biomedicine, University of Michigan, Ann Arbor, 48109, MI, United States

Source: Biomedicines Published:2023

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a solid tumor characterized by poor prognosis and resistance to treatment. Resistance to apoptosis, a cell death process, and anti-apoptotic mechanisms, are some of the hallmarks of cancer. Exploring non-apoptotic cell death mechanisms provides an opportunity to overcome apoptosis resistance in PDAC. Several recent studies evaluated ferroptosis, necroptosis, and pyroptosis as the non-apoptotic cell death processes in PDAC that play a crucial role in the prognosis and treatment of this disease. Ferroptosis, necroptosis, and pyroptosis play a crucial role in PDAC development via several signaling pathways, gene expression, and immunity regulation. This review summarizes the current understanding of how ferroptosis, necroptosis, and pyroptosis interact with signaling pathways, the genome, the immune system, the metabolism, and other factors in the prognosis and treatment of PDAC. © 2023 by the authors.

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Style	Citing Format
MLA	Barar E, Shi J. "Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death?." Biomedicines, vol. 11, no. 10, 2023, pp. -.
APA	Barar E, Shi J (2023). Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death?. Biomedicines, 11(10), -.
Chicago	Barar E, Shi J. "Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death?." Biomedicines 11, no. 10 (2023): -.
Harvard	Barar E, Shi J (2023) 'Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death?', Biomedicines, 11(10), pp. -.
Vancouver	Barar E, Shi J. Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death?. Biomedicines. 2023;11(10):-.
BibTex	@article{ author = {Barar E and Shi J}, title = {Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death?}, journal = {Biomedicines}, volume = {11}, number = {10}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Barar E AU - Shi J TI - Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate Through Non-Apoptotic Cell Death? JO - Biomedicines VL - 11 IS - 10 SP - EP - PY - 2023 ER -

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