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Low Level of Adiponectin Predicts the Development of Nonalcoholic Fatty Liver Disease: Is It Irrespective to Visceral Adiposity Index, Visceral Adipose Tissue Thickness and Other Obesity Indices? Publisher Pubmed



Ebrahimi R1 ; Shanaki M2 ; Mohassel Azadi S1 ; Bahiraee A3 ; Radmard AR4 ; Poustchi H5 ; Emamgholipour S1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Laboratory Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  4. 4. Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2022


Abstract

We aimed to study the correlation of adiponectin level with insulin resistance (IR), carotid intima-media thickness (cIMT), and various obesity indices especially visceral adipose tissue (VAT) thickness, and visceral adiposity index (VAI), in patients with NAFLD (n = 41), T2D (n = 22), NAFLD + T2D (n = 41), and healthy subjects (n = 20). Results showed the median level of adiponectin in patients with NAFLD (2.97 μg/mL) and ones with NAFLD + T2D (3.21 μg/mL) is significantly lower rather than in controls (4.39 μg/mL). Moreover, VAI is the only predictor for adiponectin concentration in the combination of patient groups and also in all participants independent of IR and other obesity indices. Adiponectin level had also a positive correlation with cIMT and IR in NAFLD patients. Interestingly, lower level of adiponectin was associated with the presence of T2D, NAFLD, and NAFLD + T2D independent of IR and obesity indices. Collectively, it seems that VAI reflecting visceral adipose tissue function is a possible predictor of adiponectin level. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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