Association of Carotid Intima Media Thickness With Atherogenic Index of Plasma, Apo B/Apo A-I Ratio and Paraoxonase Activity in Patients With Non-Alcoholic Fatty Liver Disease Publisher Pubmed



Fadaei R¹ ; Meshkani R¹ ; Poustchi H^{2, 3} ; Fallah S⁴ ; Moradi N⁵ ; Panahi G¹ ; Merat S^{2, 3} ; Golmohammadi T¹ Show Affiliations
Source: Archives of Physiology and Biochemistry Published:2019

Abstract

Background: NAFLD patients have higher risk of atherosclerosis cardiovascular disease (ASCVD). apo B/apoA-I ratio and atherogenic index of plasma (AIP) have been suggested as biomarker for ASCVD. Methods: apo A-I, apoB, aryl esterase (ARE) and paraoxonase (PON) activities and carotid intima media thickness (cIMT) were determined in 49 NAFLD patients and 33 controls. Results: Plasma levels of apo A-I, adiponectin, ARE and PON activities decreased in NAFLD patients, while apo B, AIP and apoB/apo A-I ratio level were higher in NAFLD patients compared to controls. Furthermore, cIMT showed a positive association with AIP, apo B/apo A-I ratio and AIP + (apo B/apo A-I) in NAFLD patients. Strikingly, AIP + (apo B/apo A-I) showed a good ability to discriminating increased cIMT in NAFLD patients. Conclusions: The result showed that AIP and apo B/apo A-I associated with cIMT in NAFLD patients; however, more study are needed to prove this concept. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.