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The Importance of Paying Attention to the Role of Lipid-Lowering Drugs in Controlling Dengue Virus Infection Publisher Pubmed



Allela OQB1 ; Ghazanfari Hashemi M2 ; Heidari SM3 ; Kareem RA4 ; Sameer HN5 ; Adil M6 ; Kalavi S7
Authors
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Authors Affiliations
  1. 1. College of Pharmacy, Alnoor University, Nineveh, Iraq
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Pediatric Department, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Ahl Al Bayt University, Kerbala, Iraq
  5. 5. Collage of Pharmacy, National University of Science and Technology, Dhi Qar, Nasiriyah, 64001, Iraq
  6. 6. Pharmacy College, Al-Farahidi University, Baghdad, Iraq
  7. 7. Department of Clinical Pharmacy, Faculty of Pharmacy, Islamic Azad University of Medical Sciences, Tehran, Iran

Source: Virology Journal Published:2024


Abstract

The Flaviviridae family includes the dengue virus (DENV). About half of the world’s population is in danger because of the estimated 390 million infections and 96 million symptomatic cases that occur each year. An effective treatment for dengue fever (DF) does not yet exist. Therefore, a better knowledge of how viral proteins and virus-targeted medicines may exert distinct functions depending on the exact cellular region addressed may aid in creating much-needed antiviral medications. Lipids facilitate the coordination of many viral replication phases, from entrance to dissemination. In addition, flaviviruses masterfully plan a significant rearrangement of the host cell’s lipid metabolism to foster the growth of new viruses. Recent research has consistently shown the significance of certain lipid classes in flavivirus infections. For instance, in DENV-infected cells, overall cellular cholesterol (CHO) levels are only a little altered, and DENV replication is significantly reduced when CHO metabolism is inhibited. Moreover, statins significantly decrease DENV serotype 2 (DENV-2) titers, indicating that CHO is a prerequisite for the dengue viral cycle. Furthermore, many Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are now being evaluated in human research. A new pharmacological target for the management of high CHO is PCSK9. Moreover, suppression of PCSK9 has been proposed as a possible defense against DENV. Numerous studies have generally recommended the use of lipid-lowering medications to suppress the DENV. As a result, we have investigated the DENV and popular treatment techniques in this research. We have also examined how lipid metabolism, cellular lipids, and lipid receptors affect DENV replication regulation. Lastly, we have looked at how different lipid-lowering medications affect the DENV. This article also discusses the treatment method’s future based on its benefits and drawbacks. © The Author(s) 2024.
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