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Antiviral Effects of Statins Publisher Pubmed



Gorabi AM1 ; Kiaie N1 ; Bianconi V2 ; Jamialahmadi T3, 4, 5 ; Alrasadi K6 ; Johnston TP7 ; Pirro M2 ; Sahebkar A8, 9, 10, 11
Authors
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Authors Affiliations
  1. 1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy
  3. 3. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran
  5. 5. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Oman
  7. 7. Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, United States
  8. 8. Halal Research Center of IRI, FDA, Tehran, Iran
  9. 9. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  11. 11. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

Source: Progress in Lipid Research Published:2020


Abstract

Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported. © 2020
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