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An Alternative Method for Custom Prime: A Case Report of Successful Peripheral Blood Stem Cell Harvesting From Two Low-Weight Child Donors Publisher Pubmed



Mohammadi AM1 ; Norooznezhad AH1 ; Aminian P1 ; Nikbakht M1 ; Chahardouli B1 ; Rostami S1 ; Heshmati F2 ; Mohammadi S1 ; Ghavamzadeh A1
Authors

Source: Transfusion and Apheresis Science Published:2017


Abstract

Allogeneic peripheral blood stem cell (APBSCs) transplantation is an effective treatment for hematological malignancies. However low-weight donor children meet some complications. In the current report, PBSCs were harvested from a 14-month-old child (9.8 Kg) for a 6 years old sibling recipient suffering from pre-B type of acute lymphoblastic leukemia (ALL) and also 24 months old male child donor (12 Kg) for a haploidentical recipient suffering from acute myeloid leukemia (AML-M4EO). The PBSC harvesting was performed using Spectra™ Optia® apheresis software with continuous mononuclear cell (CMNC) procedure. The results were completely promising and both recipients underwent an acceptable transplantation. © 2017 Elsevier Ltd
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