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The Association of Seasonal Variations and Covid-19 Clinical Features: A Comparative Study on the Fourth and Fifth Waves Publisher Pubmed



Karvandian K1 ; Tadbir Vajargah K2 ; Beigi S1 ; Mohammadzadeh N3 ; Ashouri M3 ; Samadi S1 ; Zamani M1
Authors
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Authors Affiliations
  1. 1. Department of Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Clinical Practice Published:2022


Abstract

Purpose. The COVID-19 pandemic has overwhelmed many healthcare systems. Seasonality is a feature of several infectious diseases. Studies regarding the association of seasonal variations and COVID-19 have shown controversial results. Therefore, we aimed to compare COVID-19 characteristics and survival outcomes between the fourth and fifth waves in Iran, which corresponded to spring and summer, respectively. Methods. This is a retrospective study on the fourth and fifth COVID-19 waves in Iran. One hundred patients from the fourth and 90 patients from the fifth wave were included. Data from the baseline and demographic characteristics, clinical, radiological, and laboratory findings, and hospital outcomes were compared between the fourth and fifth COVID-19 waves in hospitalized patients in Imam Khomeini Hospital Complex, Tehran, Iran. Results. The fifth wave patients were more likely to present with gastrointestinal symptoms than the patients from the fourth wave. Moreover, patients in the fifth wave had lower arterial oxygen saturation on admission (88% vs. 90%; P=0.026), lower levels of WBCs (neutrophils and lymphocytes) (6300.00 vs. 8000.00; P=0.004), and higher percentages of pulmonary involvement in the chest CT scans (50% vs. 40%; P<0.001). Furthermore, these patients had longer hospital stays than their fourth-wave counterparts (7.00 vs. 5.00; P<0.001). Conclusions. Our study indicated that patients in the summer COVID-19 wave were more likely to present with gastrointestinal symptoms. They also experienced a more severe disease in terms of peripheral capillary oxygen saturation, percentages of pulmonary involvement in CT scans, and length of hospital stay. © 2022 Kasra Karvandian et al.