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The Role of Stem Cells in the Treatment of Cerebral Palsy: A Review Publisher Pubmed



Kiasatdolatabadi A1 ; Lotfibakhshaiesh N1 ; Yazdankhah M1, 2 ; Ebrahimibarough S1 ; Jafarabadi M3 ; Ai A4 ; Sadroddiny E5 ; Ai J1
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of medical sciences, 88, 10th floor, Italia Str., Keshavarz Blv, Tehran, Iran
  2. 2. Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
  3. 3. Reproductive health research centre, Tehran University of medical sciences, Tehran, Iran
  4. 4. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran

Source: Molecular Neurobiology Published:2017


Abstract

Cerebral palsy (CP) is a neuromuscular disease due to injury in the infant’s brain. The CP disorder causes many neurologic dysfunctions in the patient. Various treatment methods have been used for the management of CP disorder. However, there has been no absolute cure for this condition. Furthermore, some of the procedures which are currently used for relief of symptoms in CP cause discomfort or side effects in the patient. Recently, stem cell therapy has attracted a huge interest as a new therapeutic method for treatment of CP. Several investigations in animal and human with CP have demonstrated positive potential of stem cell transplantation for the treatment of CP disorder. The ultimate goal of this therapeutic method is to harness the regenerative capacity of the stem cells causing a formation of new tissues to replace the damaged tissue. During the recent years, there have been many investigations on stem cell therapy. However, there are still many unclear issues regarding this method and high effort is needed to create a technology as a perfect treatment. This review will discuss the scientific background of stem cell therapy for cerebral palsy including evidences from current clinical trials. © 2016, Springer Science+Business Media New York.
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