Liver Regeneration Publisher



Katoonizadeh A¹ Show Affiliations
Source: Liver Pathophysiology: Therapies and Antioxidants Published:2017

Abstract

Despite a very slow cell turnover rate in healthy liver, the damaged liver has an amazing capacity to regenerate itself. This regenerative capability of the liver is highly complex and involves, depending on the type and severity of the liver injury, cross talk between numerous resident hepatic cells and recruited bone marrow cells. Two main mechanisms account for the restoration of the liver mass after injury: proliferation of existing individual cell types being mainly hepatocytes (stem cell-independent mechanism) or transdifferentiation from stem cells/hepatic progenitor cells (stem cell-dependent mechanism). Although the two mechanisms are not entirely mutually exclusive, the relative degree of their contribution to liver repopulation has not been addressed adequately. This chapter provides the most recent data regarding the contribution of different cell types and their products as well as numerous signaling pathways, in several models of regenerating liver. © 2017 Elsevier Inc. All rights reserved.