Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran

Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran Publisher Pubmed

Wu Z¹ ; Han Y² ; Caporaso JG³ ; Bokulich N³ ; Mohamadkhani A⁴ ; Moayyedkazemi A^{5, 6} ; Hua X² ; Kamangar F⁷ ; Wan Y² ; Suman S^{8, 9} ; Zhu B^{8, 9} ; Hutchinson A^{8, 9} ; Dagnall C^{8, 9} ; Jones K^{8, 9} Show All Authors

Wu Z¹
Han Y²
Caporaso JG³
Bokulich N³
Mohamadkhani A⁴
Moayyedkazemi A^{5, 6}
Hua X²
Kamangar F⁷
Wan Y²
Suman S^{8, 9}
Zhu B^{8, 9}
Hutchinson A^{8, 9}
Dagnall C^{8, 9}
Jones K^{8, 9}
Hicks B^{8, 9}
Shi J²
Malekzadeh R^{4, 10}
Abnet CC¹
Pourshams A^{4, 6}
Vogtmann E¹

Show Affiliations

1. Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
2. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
3. Center for Applied Microbiome Science, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States
4. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
6. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, United States
8. Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
9. Leidos Biomedical Research Laboratory, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States
10. Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Microbiology Spectrum Published:2021

Abstract

Cigarettes and opium contain chemicals and particulate matter that may modify the oral microbiota. This study aimed to investigate the association between cigarette and opium use with the oral microbiota. A total of 558 participants were recruited from Iran between 2011 and 2015. Individuals were categorized as never cigarette nor opium users, ever cigarette-only smokers, ever opium-only users, and ever both cigarette and opium users. Participants provided saliva samples for 16S rRNA gene sequencing. Logistic regression, microbiome regression-based kernel association test (MiRKAT), and zero-inflated beta regression models were calculated. For every increase in 10 observed amplicon sequence variants (ASVs), the odds for being a cigarette-only smoker, opium-only user, and both user compared to never users decreased by 9% (odds ratio [OR] = 0.91; 95% confidence interval [95% CI] = 0.86 to 0.97), 13% (OR = 0.87; 95% CI = 0.75 to 1.01), and 12% (OR = 0.88; 95% CI = 0.80 to 0.96), respectively. The microbial communities differed by cigarette and opium use as indicated by MiRKAT models testing the three beta-diversity matrices (P, 0.05 for all). Three genera were less likely and one genus was more likely to be detected in cigarette-only smokers or opium-only users than in never users. The relative abundance of the phylum Actinobacteria (never, 14.78%; both, 21.20%) was higher and the phyla Bacteroidetes (never, 17.63%; both, 11.62%) and Proteobacteria (never, 9.06%; both, 3.70%) were lower in users of both cigarettes and opium, while the phylum Firmicutes (never, 54.29%; opium, 65.49%) was higher in opium-only users. Cigarette and opium use was associated with lower alpha-diversity, overall oral microbiota community composition, and both the presence and relative abundance of multiple taxa. © 2021 American Society for Microbiology. All rights reserved.

2. The Association of Oral Microbiome Dysbiosis With Gastrointestinal Cancers and Its Diagnostic Efficacy, Journal of Gastrointestinal Cancer (2023)

3. The Structure and Diversity of Microbial Communities in Paederus Fuscipes (Coleoptera: Staphylinidae): From Ecological Paradigm to Pathobiome, Microbiome (2023)

4. Oral Microbiota in Cancer: Could the Bad Guy Turn Good With Application of Polyphenols?, Expert Reviews in Molecular Medicine (2023)

5. The Role of Bacterial and Fungal Human Respiratory Microbiota in Covid-19 Patients, BioMed Research International (2021)

6. Epidemiology and Prevalence of Tobacco Use in Tehran; a Report From the Recruitment Phase of Tehran Cohort Study, BMC Public Health (2023)

7. Comparison of Fecal and Oral Collection Methods for Studies of the Human Microbiota in Two Iranian Cohorts, BMC Microbiology (2021)

Experts (# of related papers)

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Reza Malekzadeh (2)

Mohammad Ali Boroumand (1)

Style	Citing Format
MLA	Wu Z, et al.. "Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran." Microbiology Spectrum, vol. 9, no. 2, 2021, pp. -.
APA	Wu Z, Han Y, Caporaso JG, Bokulich N, Mohamadkhani A, Moayyedkazemi A, Hua X, Kamangar F, Wan Y, Suman S, Zhu B, Hutchinson A, Dagnall C, Jones K, Hicks B, Shi J, Malekzadeh R, Abnet CC, Pourshams A, Vogtmann E (2021). Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran. Microbiology Spectrum, 9(2), -.
Chicago	Wu Z, Han Y, Caporaso JG, Bokulich N, Mohamadkhani A, Moayyedkazemi A, Hua X, et al.. "Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran." Microbiology Spectrum 9, no. 2 (2021): -.
Harvard	Wu Z et al. (2021) 'Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran', Microbiology Spectrum, 9(2), pp. -.
Vancouver	Wu Z, Han Y, Caporaso JG, Bokulich N, Mohamadkhani A, Moayyedkazemi A, et al.. Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran. Microbiology Spectrum. 2021;9(2):-.
BibTex	@article{ author = {Wu Z and Han Y and Caporaso JG and Bokulich N and Mohamadkhani A and Moayyedkazemi A and Hua X and Kamangar F and Wan Y and Suman S and Zhu B and Hutchinson A and Dagnall C and Jones K and Hicks B and Shi J and Malekzadeh R and Abnet CC and Pourshams A and Vogtmann E}, title = {Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran}, journal = {Microbiology Spectrum}, volume = {9}, number = {2}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Wu Z AU - Han Y AU - Caporaso JG AU - Bokulich N AU - Mohamadkhani A AU - Moayyedkazemi A AU - Hua X AU - Kamangar F AU - Wan Y AU - Suman S AU - Zhu B AU - Hutchinson A AU - Dagnall C AU - Jones K AU - Hicks B AU - Shi J AU - Malekzadeh R AU - Abnet CC AU - Pourshams A AU - Vogtmann E TI - Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran JO - Microbiology Spectrum VL - 9 IS - 2 SP - EP - PY - 2021 ER -

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