Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Oral Microbial Community Composition Is Associated With Pancreatic Cancer: A Case-Control Study in Iran Publisher Pubmed



Vogtmann E1 ; Han Y2 ; Caporaso JG3 ; Bokulich N3 ; Mohamadkhani A4 ; Moayyedkazemi A5, 6 ; Hua X2 ; Kamangar F7 ; Wan Y2 ; Suman S8, 9 ; Zhu B8, 9 ; Hutchinson A8, 9 ; Dagnall C8, 9 ; Jones K8, 9 Show All Authors
Authors
  1. Vogtmann E1
  2. Han Y2
  3. Caporaso JG3
  4. Bokulich N3
  5. Mohamadkhani A4
  6. Moayyedkazemi A5, 6
  7. Hua X2
  8. Kamangar F7
  9. Wan Y2
  10. Suman S8, 9
  11. Zhu B8, 9
  12. Hutchinson A8, 9
  13. Dagnall C8, 9
  14. Jones K8, 9
  15. Hicks B8, 9
  16. Shi J2
  17. Malekzadeh R4, 10
  18. Abnet CC1
  19. Pourshams A4, 6
Show Affiliations
Authors Affiliations
  1. 1. Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
  2. 2. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
  3. 3. Center for Applied Microbiome Science, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States
  4. 4. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  6. 6. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, United States
  8. 8. Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
  9. 9. Leidos Biomedical Research Laboratory, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States
  10. 10. Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cancer Medicine Published:2020


Abstract

Background: Oral microbiota may be related to pancreatic cancer risk because periodontal disease, a condition linked to multiple specific microbes, has been associated with increased risk of pancreatic cancer. We evaluated the association between oral microbiota and pancreatic cancer in Iran. Methods: A total of 273 pancreatic adenocarcinoma cases and 285 controls recruited from tertiary hospitals and a specialty clinic in Tehran, Iran provided saliva samples and filled out a questionnaire regarding demographics and lifestyle characteristics. DNA was extracted from saliva and the V4 region of the 16S rRNA gene was PCR amplified and sequenced on the MiSeq. The sequencing data were processed using the DADA2 plugin in QIIME 2 and taxonomy was assigned against the Human Oral Microbiome Database. Logistic regression and MiRKAT models were calculated with adjustment for potential confounders. Results: No association was observed for alpha diversity with an average of 91.11 (standard deviation [SD] 2.59) sequence variants for cases and 89.42 (SD 2.58) for controls. However, there was evidence for an association between beta diversity and case status. The association between the Bray-Curtis dissimilarity and pancreatic cancer was particularly strong with a MiRKAT P-value of.000142 and specific principal coordinate vectors had strong associations with cancer risk. Several specific taxa were also associated with case status after adjustment for multiple comparisons. Conclusion: The overall microbial community appeared to differ between pancreatic cancer cases and controls. Whether these reflect differences evident before development of pancreatic cancer will need to be evaluated in prospective studies. Published 2019. This article is a U.S. Government work and is in the public domain in the USA. Cancer Medicine published by John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Comparison of Fecal and Oral Collection Methods for Studies of the Human Microbiota in Two Iranian Cohorts, BMC Microbiology (2021)
2. The Association of Oral Microbiome Dysbiosis With Gastrointestinal Cancers and Its Diagnostic Efficacy, Journal of Gastrointestinal Cancer (2023)
3. Cigarette Smoking and Opium Use in Relation to the Oral Microbiota in Iran, Microbiology Spectrum (2021)
4. Microbiota Alterations and Their Association With Oncogenomic Changes in Pancreatic Cancer Patients, International Journal of Molecular Sciences (2021)
5. Oral Microbiota As Novel Biomarkers for Colorectal Cancer Screening, Cancers (2023)
6. The Structure and Diversity of Microbial Communities in Paederus Fuscipes (Coleoptera: Staphylinidae): From Ecological Paradigm to Pathobiome, Microbiome (2023)
7. The Prevalence Rate of Porphyromonas Gingivalis and Its Association With Cancer: A Systematic Review and Meta-Analysis, International Journal of Immunopathology and Pharmacology (2015)
8. 16S Rrna Sequencing Analysis of the Oral and Fecal Microbiota in Colorectal Cancer Positives Versus Colorectal Cancer Negatives in Iranian Population, Gut Pathogens (2024)
Experts (# of related papers)
View all Related Experts
Reza Malekzadeh (5)
Reza Ghanbari (4)
Other Related Docs
9. Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study, Cancer Prevention Research (2021)
10. Dental Health and Lung Cancer Risk in the Golestan Cohort Study, BMC Cancer (2024)
11. Human Microbiome and Prostate Cancer Development: Current Insights Into the Prevention and Treatment, Frontiers of Medicine (2021)
12. Metformin Induces Weight Loss Associated With Gut Microbiota Alteration in Non-Diabetic Obese Women: A Randomized Double-Blind Clinical Trial, European Journal of Endocrinology (2019)
13. Fecal Profiling Reveals a Common Microbial Signature for Pancreatic Cancer in Finnish and Iranian Cohorts, Gut Pathogens (2025)
14. Repeatability and Reproducibility Assessment in a Large-Scale Population-Based Microbiota Study: Case Study on Human Milk Microbiota, Microbiome (2021)
15. Oncogenomic Changes in Pancreatic Cancer and Their Detection in Stool, Biomolecules (2022)
16. Oral Microbiota in Cancer: Could the Bad Guy Turn Good With Application of Polyphenols?, Expert Reviews in Molecular Medicine (2023)
17. Variations of Gastric Corpus Microbiota Are Associated With Early Esophageal Squamous Cell Carcinoma and Squamous Dysplasia, Scientific Reports (2015)
18. Role of Microbiota-Derived Short-Chain Fatty Acids in Cancer Development and Prevention, Biomedicine and Pharmacotherapy (2021)