Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives

Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives Publisher

Zarei S¹ ; Komeili G² ; Bahadorikhalili S³ ; Yahyameymandi A⁴ ; Karamizarandi M¹ ; Larijani B⁵ ; Biglar M² ; Sadat Ebrahimi SE² ; Mahdavi M⁵

Show Affiliations

1. Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
4. Department of Chemistry, Faculty of Science, University of Birjand, Birjand, Iran
5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Heterocyclic Chemistry Published:2020

Abstract

In this paper, a novel series of 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide derivatives are synthesized in two steps. The first step involved Ugi multicomponent reaction of β-alanine, o-(propargyl)benzaldehyde and isocyanide derivatives. The product of this step, underwent a click 1,3-dipolar cycloaddition reaction with benzyl azide derivatives. The 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide product was characterized and their antibacterial activities were evaluated against various G-positive (Staphylococcus aureus and Bacillus subtilis) and G-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria, using minimal inhibition concentration. The compounds showed very good antimicrobial activity and a number of products have been more active than ciprofloxacin. © 2020 Wiley Periodicals LLC.

Experts (# of related papers)

Seyed Jamaledin Shataheri (1)

Farideh Golbabaei (1)

Style	Citing Format
MLA	Zarei S, et al.. "Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives." Journal of Heterocyclic Chemistry, vol. 57, no. 12, 2020, pp. 4254-4261.
APA	Zarei S, Komeili G, Bahadorikhalili S, Yahyameymandi A, Karamizarandi M, Larijani B, Biglar M, Sadat Ebrahimi SE, Mahdavi M (2020). Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives. Journal of Heterocyclic Chemistry, 57(12), 4254-4261.
Chicago	Zarei S, Komeili G, Bahadorikhalili S, Yahyameymandi A, Karamizarandi M, Larijani B, Biglar M, Sadat Ebrahimi SE, Mahdavi M. "Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives." Journal of Heterocyclic Chemistry 57, no. 12 (2020): 4254-4261.
Harvard	Zarei S et al. (2020) 'Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives', Journal of Heterocyclic Chemistry, 57(12), pp. 4254-4261.
Vancouver	Zarei S, Komeili G, Bahadorikhalili S, Yahyameymandi A, Karamizarandi M, Larijani B, et al.. Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives. Journal of Heterocyclic Chemistry. 2020;57(12):4254-4261.
BibTex	@article{ author = {Zarei S and Komeili G and Bahadorikhalili S and Yahyameymandi A and Karamizarandi M and Larijani B and Biglar M and Sadat Ebrahimi SE and Mahdavi M}, title = {Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives}, journal = {Journal of Heterocyclic Chemistry}, volume = {57}, number = {12}, pages = {4254-4261}, year = {2020} }
RIS	TY - JOUR AU - Zarei S AU - Komeili G AU - Bahadorikhalili S AU - Yahyameymandi A AU - Karamizarandi M AU - Larijani B AU - Biglar M AU - Sadat Ebrahimi SE AU - Mahdavi M TI - Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives JO - Journal of Heterocyclic Chemistry VL - 57 IS - 12 SP - 4254 EP - 4261 PY - 2020 ER -

Style

Citing Format

MLA

Zarei S, et al.. "Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives." Journal of Heterocyclic Chemistry, vol. 57, no. 12, 2020, pp. 4254-4261.

APA

Zarei S, Komeili G, Bahadorikhalili S, Yahyameymandi A, Karamizarandi M, Larijani B, Biglar M, Sadat Ebrahimi SE, Mahdavi M (2020). Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives. Journal of Heterocyclic Chemistry, 57(12), 4254-4261.

Chicago

Zarei S, Komeili G, Bahadorikhalili S, Yahyameymandi A, Karamizarandi M, Larijani B, Biglar M, Sadat Ebrahimi SE, Mahdavi M. "Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives." Journal of Heterocyclic Chemistry 57, no. 12 (2020): 4254-4261.

Harvard

Zarei S et al. (2020) 'Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives', Journal of Heterocyclic Chemistry, 57(12), pp. 4254-4261.

Vancouver

Zarei S, Komeili G, Bahadorikhalili S, Yahyameymandi A, Karamizarandi M, Larijani B, et al.. Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives. Journal of Heterocyclic Chemistry. 2020;57(12):4254-4261.

BibTex

@article{ author = {Zarei S and Komeili G and Bahadorikhalili S and Yahyameymandi A and Karamizarandi M and Larijani B and Biglar M and Sadat Ebrahimi SE and Mahdavi M}, title = {Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives}, journal = {Journal of Heterocyclic Chemistry}, volume = {57}, number = {12}, pages = {4254-4261}, year = {2020} }

RIS

TY - JOUR
AU - Zarei S
AU - Komeili G
AU - Bahadorikhalili S
AU - Yahyameymandi A
AU - Karamizarandi M
AU - Larijani B
AU - Biglar M
AU - Sadat Ebrahimi SE
AU - Mahdavi M
TI - Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives
JO - Journal of Heterocyclic Chemistry
VL - 57
IS - 12
SP - 4254
EP - 4261
PY - 2020
ER -

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