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Controlling Cell Behavior Through the Design of Biomaterial Surfaces: A Focus on Surface Modification Techniques Publisher



Amani H1 ; Arzaghi H2 ; Bayandori M1 ; Dezfuli AS3, 4 ; Pazokitoroudi H5 ; Shafiee A6, 7 ; Moradi L8
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Biotechnology, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, 449614535, Iran
  4. 4. Young Researchers and Elite Club, Shahr-e-Qods Branch, Islamic Azad University, Tehran, 37515-374, Iran
  5. 5. Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Centre in Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, 4059, QLD, Australia
  7. 7. UQ Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, 4102, QLD, Australia
  8. 8. Pediatric Urology and Regenerative Medicine Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, 1417613151, Iran

Source: Advanced Materials Interfaces Published:2019


Abstract

Surface interaction at the biomaterial–cell interface is essential for a variety of cellular functions, such as adhesion, proliferation, and differentiation. Nevertheless, changes in the biointerface enable to trigger specific cell signaling and result in different cellular responses. In order to manufacture biomaterials with higher functionality, biomaterials containing immobilized bioactive ligands have been widely introduced and employed for tissue engineering and regenerative medicine applications. Moreover, a number of physical and chemical strategies have been used to improve the functionality of biomaterials and specifically at the material interface. Here, the interactions between materials and cells at the interface levels are described. Then, the importance of surface properties in cell function is discussed and recent methods for surface modifications are systematically highlighted. Additionally, the impact of bulk material properties on the cellular responses is briefly reviewed. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim