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Horseradish Peroxidase-Catalyzed Hydrogelation for Biomedical Applications Publisher Pubmed



Khanmohammadi M1 ; Dastjerdi MB2 ; Ai A3 ; Ahmadi A4 ; Godarzi A1 ; Rahimi A1 ; Ai J1
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, Sch. of Adv. Technol. in Med., Tehran Univ. of Med. Sciences, Tehran, Iran
  2. 2. Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Iran

Source: Biomaterials Science Published:2018


Abstract

Hydrogels catalyzed by horseradish peroxidase (HRP) serve as an efficient and effective platform for biomedical applications due to their mild reaction conditions for cells, fast and adjustable gelation rate in physiological conditions, and an abundance of substrates as water-soluble biocompatible polymers. In this review, we highlight the tunable characteristics and use of the HRP-catalyzed hydrogels and provide a brief overview of various substrates employed in the HRP system for different biomedical applications of the resultant hydrogels. In addition, we discuss and summarize the biocompatibility, possible functionalization, and biofabrication process. Finally, the future prospective of the HRP crosslinking system is highlighted with biomedical applications. © The Royal Society of Chemistry 2018.
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