Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art

Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art Publisher Pubmed

Gorabi AM¹ ; Bianconi V² ; Pirro M² ; Banach M^{3, 4} ; Sahebkar A^{5, 6, 7}

Show Affiliations

1. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
2. Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine, University of Perugia, Perugia, Italy
3. Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, Poland
4. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland
5. Halal Research Center of IRI, FDA, Tehran, Iran
6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
7. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Biomedicine and Pharmacotherapy Published:2019

Abstract

Stem cells have a therapeutic potential in various medical conditions. In cases without sufficient response to conventional drug treatments, stem cells represent a next generation therapeutic strategy in cardiovascular diseases. Cardiac stem cells (CSCs), among a wide variety of stem cell sources, have been identified as a valid option for stem cell-based therapy in cardiovascular diseases. CSCs mainly act as a cell source to supply the physiological need for cardiovascular cells. However, they have been demonstrated to reproduce the myocardial cells under pathological settings. Despite their roles and functions have somewhat been clarified, molecular pathways underlying the regulatory mechanisms of CSCs are still not fully elucidated. Several studies have recently shown that different microRNAs (miRNAs) play a substantial role in regulating and controlling both the physiological and pathological proliferation and differentiation of stem cells. MiRNAs are small non-coding RNA molecules that regulate gene expression and may undergo aberrant expression levels during pathological conditions. Understanding the way through which miRNAs regulate CSC behavior may open up new horizons in modulating these cells in vitro to devise sophisticated approaches for treating patients with cardiovascular diseases. In this review article, we tried to discuss available evidence about the role of miRNAs in regulating CSCs. © 2019 The Authors

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Style	Citing Format
MLA	Gorabi AM, et al.. "Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art." Biomedicine and Pharmacotherapy, vol. 120, no. , 2019, pp. -.
APA	Gorabi AM, Bianconi V, Pirro M, Banach M, Sahebkar A (2019). Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art. Biomedicine and Pharmacotherapy, 120(), -.
Chicago	Gorabi AM, Bianconi V, Pirro M, Banach M, Sahebkar A. "Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art." Biomedicine and Pharmacotherapy 120, no. (2019): -.
Harvard	Gorabi AM et al. (2019) 'Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art', Biomedicine and Pharmacotherapy, 120(), pp. -.
Vancouver	Gorabi AM, Bianconi V, Pirro M, Banach M, Sahebkar A. Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art. Biomedicine and Pharmacotherapy. 2019;120():-.
BibTex	@article{ author = {Gorabi AM and Bianconi V and Pirro M and Banach M and Sahebkar A}, title = {Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art}, journal = {Biomedicine and Pharmacotherapy}, volume = {120}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Gorabi AM AU - Bianconi V AU - Pirro M AU - Banach M AU - Sahebkar A TI - Regulation of Cardiac Stem Cells by Micrornas: State-Of-The-Art JO - Biomedicine and Pharmacotherapy VL - 120 IS - SP - EP - PY - 2019 ER -

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