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Osteogenesis Capability of Three-Dimensionally Printed Poly(Lactic Acid)-Halloysite Nanotube Scaffolds Containing Strontium Ranelate Publisher



Boraei SBA1 ; Nourmohammadi J2 ; Mahdavi FS3 ; Zare Y1 ; Rhee KY4 ; Montero AF5 ; Herencia AJS5 ; Ferrari B5
Authors
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Authors Affiliations
  1. 1. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Tehran, Iran
  2. 2. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
  3. 3. Department of Biotechnology, University of Tehran, Tehran, Iran
  4. 4. Department of Mechanical Engineering (BK21 Four), College of Engineering, Kyung Hee University, Yongin, South Korea
  5. 5. Institute of Ceramic and Glass, CSIC, C/Kelsen 5, Madrid, 28010, Spain

Source: Nanotechnology Reviews Published:2022


Abstract

In this study, three-dimensional (3D) printing of 3D scaffolds containing halloysite nanotubes (HNTs) and strontium ranelate (SrR) as a carrier for the promotion of bone regeneration is investigated. SrR acts as an anabolic bone-forming and anti-catabolic agent, while HNTs act as a carrier of SrR. Poly(lactic acid) (PLA) is used as a biodegradable matrix and carrier for HNTs and SrR. The effects of the SrR addition on the morphological, biological, and in vitro release properties of the scaffolds are evaluated. The morphological results show a homogeneous structure with a proper pore size (approximately 400 μm) suitable for osteogenesis. The contact angle is decreased after the addition of SrR to the scaffold to 67.99°, suitable for cell attachment. X-ray diffraction shows that the SrR is homogenously and molecularly distributed in the PLA matrix and reduces the crystallinity in the prepared scaffolds. The in vitro release results demonstrate that the release profile of the SrR is stable, relatively linear, and continuous within 21 days (504 h). A cumulative release of SrR of approximately 49% is obtained after a controlled release for 504 h (21 days) and a low primary burst release (12%). Human adipose stem cells cultured on the 3D-printed scaffolds demonstrate that the SrR can efficiently promote biocompatibility, alkaline phosphatase activity, and alizarin red staining. © 2022 Seyyed Behnam Abdollahi Boraei et al., published by De Gruyter.
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