Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
In Vitro and In Vivo Characteristics of Doxorubicin-Loaded Cyclodextrine-Based Polyester Modified Gadolinium Oxide Nanoparticles: A Versatile Targeted Theranostic System for Tumour Chemotherapy and Molecular Resonance Imaging Publisher Pubmed



Mortezazadeh T1 ; Gholibegloo E2 ; Khoobi M2 ; Alam NR3 ; Haghgoo S4 ; Mesbahi A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Biomaterials Group, The Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical, Sciences, Tehran, Iran
  4. 4. Pharmaceutical Department, Food and Drug Laboratory Research Center, Food and Drug Organization (FDO), Ministry of Health, Tehran, Iran

Source: Journal of Drug Targeting Published:2020


Abstract

β-Cyclodextrine-based polyester was coated on the surface of gadolinium oxide nanoparticles (NPs) and then functionalised with folic acid to produce an efficient pH-sensitive targeted theranostic system (Gd2O3@PCD-FA) for doxorubicin delivery and magnetic resonance imaging (MRI). Gd2O3@PCD-FA was fully characterised by FTIR, vibrating sample magnetometer, TGA, XRD, SEM and TEM analyses. The dissolution profile of DOX showed a pH sensitive release. No significant toxicity was observed for the targeted NPs (Gd2O3@PCD-FA) and DOX-loaded NPs inhibiting M109 cells viability more efficiently than free DOX. Moreover, the negligible hemolytic activity of the targeted NPs showed their appropriate hemocompatibility. The preferential uptake was observed for the developed Gd2O3@PCD-FA-DOX NPs in comparison with Dotarem using T1- and T2-weighted MRI in the presence of folate receptor-positive and folate receptor-negative cancer cells (M109 and 4T1, respectively). Furthermore, in vivo studies revealed that Gd2O3@PCD-FA-DOX not only exhibited considerably relaxivity performance as a contrast agent for MRI, but also improved in vivo anti-tumour efficacy of the system. The results suggest that Gd2O3@PCD-FA-DOX improves its therapeutic efficacy in the treatment of solid tumours and also reduces the adverse effects, so it could be proposed as a promising drug delivery system for chemotherapy and molecular imaging diagnosis in MRI. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Gadolinium (Iii) Oxide Nanoparticles Coated With Folic Acid-Functionalized Poly(Β-Cyclodextrin-Co-Pentetic Acid) As a Biocompatible Targeted Nano-Contrast Agent for Cancer Diagnostic: In Vitro and in Vivo Studies, Magnetic Resonance Materials in Physics# Biology and Medicine (2019)
2. Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri, Journal of Biomedical Physics and Engineering (2020)
3. Folic Acid Decorated Magnetic Nanosponge: An Efficient Nanosystem for Targeted Curcumin Delivery and Magnetic Resonance Imaging, Journal of Colloid and Interface Science (2019)
4. A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies, Carbohydrate Polymers (2021)
5. Codelivery of Hydrophobic and Hydrophilic Drugs by Graphene-Decorated Magnetic Dendrimers, Langmuir (2018)
6. Curcumin-Lipoic Acid Conjugate As a Promising Anticancer Agent on the Surface of Gold‑Iron Oxide Nanocomposites: A Ph-Sensitive Targeted Drug Delivery System for Brain Cancer Theranostics, European Journal of Pharmaceutical Sciences (2018)
7. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
8. Magnetic Bio-Metal–Organic Framework Nanocomposites Decorated With Folic Acid Conjugated Chitosan As a Promising Biocompatible Targeted Theranostic System for Cancer Treatment, Materials Science and Engineering C (2019)
Experts (# of related papers)
View all Related Experts
Mehdi Khoobi (17)
Alireza Foroumadi (5)
Other Related Docs
9. Cell-Penetrating Peptidic Grp78 Ligand-Conjugated Iron Oxide Magnetic Nanoparticles for Tumor-Targeted Doxorubicin Delivery and Imaging, ACS Applied Bio Materials (2023)
10. Lymph Node Metastases Detection Using Gd2o3@Pcd As Novel Multifunctional Contrast Imaging Agent in Metabolic Magnetic Resonance Molecular Imaging, Contrast Media and Molecular Imaging (2022)
11. Β-Cyclodextrin Functionalized Poly (5-Amidoisophthalicacid) Grafted Fe3o4 Magnetic Nanoparticles: A Novel Biocompatible Nanocomposite for Targeted Docetaxel Delivery, Journal of Magnetism and Magnetic Materials (2016)
12. Amino-Modified-Silica-Coated Gadolinium-Copper Nanoclusters, Conjugated to As1411 Aptamer and Radiolabeled With Technetium-99 M As a Novel Multimodal Imaging Agent, Bioorganic Chemistry (2022)
13. In Vitro and in Silico Characteristics of Doxorubicin-Loaded Four Polymeric-Based Polysaccharides-Modified Super Paramagnetic Iron Oxide Nanoparticles for Cancer Chemotherapy and Magnetic Resonance Imaging, International Journal of Polymeric Materials and Polymeric Biomaterials (2024)
14. Polyethylenimine-Graft-Poly (Maleic Anhydride-Alt-1-Octadecene) Coated Fe3o4 Magnetic Nanoparticles: Promising Targeted Ph-Sensitive System for Curcumin Delivery and Mr Imaging, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
15. Ph-Responsive Polymer in a Core–Shell Magnetic Structure As an Efficient Carrier for Delivery of Doxorubicin to Tumor Cells, International Journal of Polymeric Materials and Polymeric Biomaterials (2018)
16. Degradation of Tetracycline Using a Magnetic Gadolinium-Decorated Nanoplatform: A Peroxidase Biomimetic System With Fenton-Like Catalysis, Water (Switzerland) (2023)
17. Application of Nano-Radiosensitizers in Combination Cancer Therapy, Bioengineering and Translational Medicine (2023)
18. Nsf Evaluation of Gadolinium Biodistribution in Renally Impaired Rats: Using Novel Metabolic Gd2o3 Nanoparticles Coated With Β-Cyclodextrin (Gd2o3@Pcd) in Mr Molecular Imaging, Magnetic Resonance Imaging (2024)
19. Glutathione Conjugated Polyethylenimine on the Surface of Fe 3 O 4 Magnetic Nanoparticles As a Theranostic Agent for Targeted and Controlled Curcumin Delivery, Journal of Biomaterials Science# Polymer Edition (2018)
20. Highly Fluorinated Graphene Oxide Nanosheets for Anticancer Linoleic-Curcumin Conjugate Delivery and T2-Weighted Magnetic Resonance Imaging: In Vitro and in Vivo Studies, Journal of Drug Delivery Science and Technology (2020)
21. The Use of Nanoparticles As a Promising Therapeutic Approach in Cancer Immunotherapy, Artificial Cells# Nanomedicine and Biotechnology (2016)
22. Improved Curcumin Loading, Release, Solubility and Toxicity by Tuning the Molar Ratio of Cross-Linker to Β-Cyclodextrin, Carbohydrate Polymers (2019)
23. Graphene Aerogel Nanoparticles for In-Situ Loading/Ph Sensitive Releasing Anticancer Drugs, Colloids and Surfaces B: Biointerfaces (2020)
24. Folate-Conjugated Nanoparticles As a Potent Therapeutic Approach in Targeted Cancer Therapy, Tumor Biology (2015)
25. Chitosan/Gamma-Alumina/Fe3o4@5-Fu Nanostructures As Promising Nanocarriers: Physiochemical Characterization and Toxicity Activity, Molecules (2022)
26. Micelle-Based Nanoparticles With Stimuli-Responsive Properties for Drug Delivery, Nanotechnology Reviews (2024)
27. Synthesis and Characterization of a Novel, Ph-Responsive Sustained Release Nanocarrier Using Polyethylene Glycol, Graphene Oxide, and Natural Silk Fibroin Protein by a Green Nano Emulsification Method to Enhance Cancer Treatment, International Journal of Biological Macromolecules (2023)
28. The Importance of Selecting a Proper Biological Milieu for Protein Corona Analysis in Vitro: Human Plasma Versus Human Serum, International Journal of Biochemistry and Cell Biology (2016)
29. Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery, Smart internal stimulus-responsive nanocarriers for drug and gene delivery (2015)
30. Metal-Organic Frameworks: A Promising Option for the Diagnosis and Treatment of Alzheimer's Disease, Journal of Controlled Release (2023)
31. Polysaccharide-Based Hydrogels Containing Herbal Extracts for Wound Healing Applications, Carbohydrate Polymers (2022)
32. Bio-Applications of Graphene Composites: From Bench to Clinic, Advanced 2D Materials (2016)
33. Synthesis and Evaluation of New Magneto-Fluorescent Carbon Dot Based on Manganese Citrate for Mri Imaging, Magnetic Resonance Materials in Physics# Biology and Medicine (2024)
34. Toxicology of Nanobiomaterials, Stem Cell Nanoengineering (2015)
35. Ph-Responsive Chitosan-Modified Gadolinium Oxide Nanoparticles Delivering 5-Aminolevulinic Acid: A Dual Cellular and Metabolic T1-T2* Contrast Agent for Glioblastoma Brain Tumors Detection, Journal of Molecular Liquids (2022)
36. Combining Nanotechnology and Gas Plasma As an Emerging Platform for Cancer Therapy: Mechanism and Therapeutic Implication, Oxidative Medicine and Cellular Longevity (2021)