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Polyethylenimine-Graft-Poly (Maleic Anhydride-Alt-1-Octadecene) Coated Fe3o4 Magnetic Nanoparticles: Promising Targeted Ph-Sensitive System for Curcumin Delivery and Mr Imaging Publisher



Molaei H1 ; Zaaeri F2 ; Sharifi S3 ; Ramazani A1 ; Safaei S4 ; Abdolmohammadi J5 ; Khoobi M6
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, University of Zanjan, Zanjan, Iran
  2. 2. Faculty of Pharmacy, Department of Pharmaceutics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Marine Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Imam Khomeini Imaging Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Paramedical, Department of Radiology, Kurdistan University of Medical Sciences, Sanandaj, Iran
  6. 6. Biomaterials Group, Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2021


Abstract

A theranostic amphiphilic nanocarrier based on iron oxide core with polyethyleneimine and poly(maleic anhydride-alt-1-octadecene) shell was synthesized, labeled with folic acid and loaded with Curcumin. Fe3O4@PIMF nanoparticles displayed a size of 20–30 nm with a shell thickness of 2–5 nm. Fe3O4@PIMF-CUR MNPs exhibited pH-responsive release behavior matched with Michaelis–Menten model. The MNPs showed more toxicity than free CUR against MCF-7 and Hela cells, while the drug-free carrier was safe against both cell lines. Hemolytic activity less than 1.5% in concentrations of <500 µg/mL indicated excellent blood compatibility. Appropriate negative signal enhancement in MRI confirmed the efficiency of the system for cancer theranostics. © 2020 Taylor & Francis Group, LLC.
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