Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Curcumin-Lipoic Acid Conjugate As a Promising Anticancer Agent on the Surface of Gold‑Iron Oxide Nanocomposites: A Ph-Sensitive Targeted Drug Delivery System for Brain Cancer Theranostics Publisher Pubmed



Ghorbani M1 ; Bigdeli B2 ; Jalilibaleh L3 ; Baharifar H4 ; Akrami M6 ; Dehghani S5 ; Goliaei B2 ; Amani A4 ; Lotfabadi A6 ; Rashedi H1 ; Haririan I6 ; Alam NR5 ; Hamedani MP7 ; Khoobi M3, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
  3. 3. Nanobiomaterials group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  4. 4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Pharmaceutical Sciences Published:2018


Abstract

Brain tumor is a lethal, fast growing cancer and a difficult case for treatment. Receptor-mediated endocytosis has been recognized as one of the most effective methods for drug delivery to brain tissue by overcoming obstacles associated with conventional therapeutics. In this work, a targeted theranostic drug delivery system (DDS) was prepared based on gold‑iron oxide nanocomposites (Fe3O4@Au NCs). Lipoic acid-curcumin (LA-CUR) was synthesized and introduced as a novel anticancer drug, and glutathione (GSH) was exploited as the targeting ligand. Both LA-CUR and GSH were easily attached to Fe3O4@Au NCs via Au-S interaction. As a negatively charged nanocarrier, the prepared DDS showed relatively less protein adsorption. Accordingly, hemocompatibility assays (complement, platelet, and leucocyte activation) revealed its hemocompatible virtue, especially in respect of free LA-CUR. GSH functionalization led to 2-fold increase of cellular uptake in GSH receptor-positive astrocyte cells which could primarily indicate the probable ability of the DDS to bypass BBB. Cytotoxicity and apoptosis assays together showed the noticeably enhanced cytotoxicity of LA-CUR against cancerous U87MG cells (IC50 = 2.69 μg/ml) in comparison with curcumin (IC50 = 21.31 μg/ml); moreover, the DDS demonstrated relatively higher cytotoxicity against cancerous U87MG cells than normal astrocyte cells which was in accordance with pH sensitive mechanism of LA-CUR release. Besides, the results of in vitro magnetic resonance imaging (MRI) (relaxation rate (r2) = 80.73 (s− 1·mM− 1)) primarily revealed that the DDS can be applied as a negative MRI contrast agent. In sum, the prepared DDS appeared to be a promising candidate for brain cancer treatment and a favorable MRI contrast agent. © 2017 Elsevier B.V.
Related Docs
View other Related Docs
1. Folic Acid Decorated Magnetic Nanosponge: An Efficient Nanosystem for Targeted Curcumin Delivery and Magnetic Resonance Imaging, Journal of Colloid and Interface Science (2019)
2. In Vitro and In Vivo Characteristics of Doxorubicin-Loaded Cyclodextrine-Based Polyester Modified Gadolinium Oxide Nanoparticles: A Versatile Targeted Theranostic System for Tumour Chemotherapy and Molecular Resonance Imaging, Journal of Drug Targeting (2020)
3. Glutathione Conjugated Polyethylenimine on the Surface of Fe 3 O 4 Magnetic Nanoparticles As a Theranostic Agent for Targeted and Controlled Curcumin Delivery, Journal of Biomaterials Science# Polymer Edition (2018)
4. Glucosamine Conjugated Gadolinium (Iii) Oxide Nanoparticles As a Novel Targeted Contrast Agent for Cancer Diagnosis in Mri, Journal of Biomedical Physics and Engineering (2020)
5. Theranostic Α-Lactalbumin-Polymer-Based Nanocomposite As a Drug Delivery Carrier for Cancer Therapy, ACS Biomaterials Science and Engineering (2019)
6. Nanobiotechnological Approaches to Overcome Drug Resistance in Breast Cancer, Current Cancer Drug Targets (2015)
7. A Biocompatible Theranostic Nanoplatform Based on Magnetic Gadolinium-Chelated Polycyclodextrin: In Vitro and in Vivo Studies, Carbohydrate Polymers (2021)
8. Evaluation of Targeted Curcumin (Cur) Loaded Plga Nanoparticles for in Vitro Photodynamic Therapy on Human Glioblastoma Cell Line, Photodiagnosis and Photodynamic Therapy (2018)
Experts (# of related papers)
View all Related Experts
Mehdi Khoobi (13)
Alireza Foroumadi (3)
Other Related Docs
9. Magnetic Bio-Metal–Organic Framework Nanocomposites Decorated With Folic Acid Conjugated Chitosan As a Promising Biocompatible Targeted Theranostic System for Cancer Treatment, Materials Science and Engineering C (2019)
10. Improved Curcumin Loading, Release, Solubility and Toxicity by Tuning the Molar Ratio of Cross-Linker to Β-Cyclodextrin, Carbohydrate Polymers (2019)
11. Targeted Drug Delivery Based on Gold Nanoparticle Derivatives, Current Pharmaceutical Design (2017)
12. Biocompatibility and Nanostructured Materials: Applications in Nanomedicine, Artificial Cells# Nanomedicine and Biotechnology (2017)
13. Overcoming the Blood-Brain Barrier in Neurodegenerative Disorders and Brain Tumours, IET Nanobiotechnology (2020)
14. Highly Fluorinated Graphene Oxide Nanosheets for Anticancer Linoleic-Curcumin Conjugate Delivery and T2-Weighted Magnetic Resonance Imaging: In Vitro and in Vivo Studies, Journal of Drug Delivery Science and Technology (2020)
15. Gold-Capped Mesoporous Silica Nanoparticles As an Excellent Enzyme-Responsive Nanocarrier for Controlled Doxorubicin Delivery, Journal of Drug Targeting (2019)
16. Nanobased Cns Delivery Systems, Nanobiomaterials: Applications in Drug Delivery (2018)
17. Effects of Dietary Supplementation With Nanocurcumin on Quality and Safety of Meat From Broiler Chicken Infected With Eimeria Species, Journal of Food Safety (2019)
18. The Synthesis and Characterization of Double Nanoemulsion for Targeted Co-Delivery of 5-Fluorouracil and Curcumin Using Ph-Sensitive Agarose/Chitosan Nanocarrier, Journal of Drug Delivery Science and Technology (2022)
19. Effect of Dietary Supplementation of Nanocurcumin on Oxidant Stability of Broiler Chicken Breast Meat Infected With Eimeria Species, Veterinary Research Forum (2020)
20. Polyethylenimine-Graft-Poly (Maleic Anhydride-Alt-1-Octadecene) Coated Fe3o4 Magnetic Nanoparticles: Promising Targeted Ph-Sensitive System for Curcumin Delivery and Mr Imaging, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
21. Nanotechnology-Based Theranostic Approaches in Brain Diseases, Theranostics Nanomaterials in Drug Delivery (2024)
22. Ph-Sensitive Biocompatible Mesoporous Magnetic Nanoparticles Labeled With Folic Acid As an Efficient Carrier for Controlled Anticancer Drug Delivery, Journal of Drug Delivery Science and Technology (2018)