Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Serum Content of 25-Hydroxy Vitamin D With Semen Quality in Normozoospermic and Oligoasthenoteratozoospermic Men



Azizi E1 ; Naji M2 ; Shabaninashtaei M1 ; Sobhani A1 ; Najafi A1 ; Amidi F1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Reproductive BioMedicine Published:2018

Abstract

Background: Vitamin D has multifaceted function in human reproductive physiology. It has been revealed that vitamin D is involved in spermatogenesis, and semen quality can be linked to vitamin D status in men. Objective: Evaluating the correlation of 25-hydroxy vitamin D (25-OHD) levels in serum with basic and advanced semen parameters and essential determinants of spermatozoa function. Materials and Methods: Participants were categorized, based on semen parameters, into normozoospermic (NS) and oligoasthenoteratozoospermic (OAT) men. Serum level of 25-OHD was measured. Apoptotic status of spermatozoa, mitochondrial membrane potential and reactive oxygen species content of semen were assessed. Results: Difference of 25-OHD concentration in serum of NS men versus OAT ones did not meet significance threshold. DNA fragmentation, reactive oxygen species content of semen and mitochondrial membrane potential state revealed significant difference between NS and OAT subjects. There were no significant differences in basic and functional semen parameters when men were stratified based on serum 25-OHD level. Taking both 25-OHD and semen categories (NS and OAT) into consideration did not indicate any significant difference in studied parameters. Total motility of spermatozoa was positively correlated with serum concentration of 25-OHD in all studied subjects. In addition, normal morphology of spermatozoa in NS men revealed a positive and significant correlation with levels of 25-OHD in serum. Conclusion: Vitamin D may affect motility and morphology of spermatozoa. Lower content of serum vitamin D may affect fertility of men and should be considered in examination of men with abnormal spermogram. © 2018, Research and Clinical Center for Infertitlity. All rights reserved.
Related Docs
View other Related Docs
1. Association of Vitamin D Status With Semen Quality and Reproductive Hormones in Iranian Subfertile Men, Andrology (2017)
2. Is There a Relationship Between Serum Vitamin D and Semen Parameters? a Cross-Sectional Sample of the Iranian Infertile Men, Basic and Clinical Andrology (2021)
3. The Association Between Serum Vitamin D Level and Sperm Parameters: A Pilot Study in a Subset of Iranian Infertile Males, Immunopathologia Persa (2020)
4. Assessment of the Relationship Between Vitamin D With Semen Analysis Parameters and Reproductive Hormones Levels Before and After Kidney Transplantation: An Iranian Randomized and Double-Blinded Study, Urologia Journal (2023)
5. Evaluation of the Relationship Between Vitamin D Levels With Oocyte Quality in Breast Cancer Women: A Cross-Sectional Study, Scientific Reports (2023)
6. Association Study of Rs2228570 Snp of the Vdr Gene With Spermatogenesis Disorders in Infertile Men in Iranian Population, Tehran University Medical Journal (2016)
7. Economic Evaluation of a National Vitamin D Supplementation Program Among Iranian Adolescents for the Prevention of Adulthood Type 2 Diabetes Mellitus, BMC Complementary Medicine and Therapies (2022)
8. Vitamin D Supplementation and Risk of Hypercalciuria in Stone Formers, Iranian Journal of Kidney Diseases (2019)
Experts (# of related papers)
View all Related Experts
Kurosh Djafarian (2)
Sakineh Shab-Bidar (2)
Other Related Docs
9. The Association Between Vitamin D Deficiency and Variants of Vitamin D Binding Protein Gene Among Healthy Iranian Adults, International Journal for Vitamin and Nutrition Research (2020)
10. Vitamin D Deficiency Associated With Reproductive Factors in Northern Iranian Women: The Persian Guilan Cohort Study (Pgcs), Clinical Nutrition ESPEN (2020)
11. Effects of Vitamin D Supplementation on 8-Hydroxydeoxy Guanosine and 3-Nitrotyrosine in Patients With Type 2 Diabetes: A Randomized Clinical Trial, Progress in Nutrition (2019)
12. The Prevalence of Vitamin D Deficiency, Its Predisposing Factors and Association With 24-Hour Urine Metabolites Among Iranian Kidney Stone Formers, Iranian Journal of Kidney Diseases (2021)
13. Effect of Vitamin D on Stress-Induced Hyperglycaemia and Insulin Resistance in Critically Ill Patients, International Journal of Clinical Practice (2016)
14. A Comprehensive, Epidemiological and Ecological Descriptive Study on Vitamin D Status in Iran (308005 People, From 2009-2018), Iranian Journal of Public Health (2019)
15. Vitamin D Represses the Aggressive Potential of Osteosarcoma, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)
16. Effect of Vitamin D Receptor Polymorphisms on Plasma Oxidative Stress and Apoptotic Biomarkers Among Breast Cancer Survivors Supplemented Vitamin D3, European Journal of Cancer Prevention (2020)
17. Serum 25-Hydroxyvitamin D Level and Vitamin D Receptor (Vdr) Polymorphisms in Patients Infected With Leishmania Tropica: A Case Control Study, Journal of Parasitic Diseases (2020)
18. Erp57 Protein Activators for Management of Fertility by Virtual Screening and Molecular Dynamic Studies, Biointerface Research in Applied Chemistry (2023)
19. The Joint Association of Serum Vitamin D Status and Cardiorespiratory Fitness With Obesity and Metabolic Syndrome in Tehranian Adults, British Journal of Nutrition (2022)
20. Cross Sectional Determinants of Vo2 Max in Free Living Iranians: Potential Role of Metabolic Syndrome Components and Vitamin D Status, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2022)
21. The Effects of Vitamin D, K and Calcium Co-Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Overweight Type 2 Diabetic Patients With Chd, British Journal of Nutrition (2016)
22. Comparable Vitamin D3 Metabolism in the Endometrium of Patients With Recurrent Spontaneous Abortion and Fertile Controls, Molecular Reproduction and Development (2015)
23. Iranian Multicenter Osteoporosis Studies (Imos) During Last Decade: Rationale, Main Findings, Lessons Learned and the Way Forward, Journal of Diabetes and Metabolic Disorders (2020)
24. The Effect of Vitamin D Supplementation on Serum Levels of Anti-Mullerian Hormone, Journal of Babol University of Medical Sciences (2025)
25. Vitamin D Sufficiency, a Serum 25-Hydroxyvitamin D at Least 30 Ng/Ml Reduced Risk for Adverse Clinical Outcomes in Patients With Covid-19 Infection, PLoS ONE (2020)
26. The Biochemical Parameters and Vitamin D Levels in Icu Patients With Covid-19: A Cross-Sectional Study, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)
27. Calcium-Vitamin D Co-Supplementation Affects Metabolic Profiles, But Not Pregnancy Outcomes, in Healthy Pregnant Women, International Journal of Preventive Medicine (2016)