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The Association Between Genetic Factors and Temporomandibular Disorders: A Systematic Literature Review Publisher Pubmed



Alshahrani AA1 ; Saini RS1 ; Okshah A1 ; Alshadidi AAF1 ; Kanji MA1 ; Vyas R1 ; Binduhayyim RIH1 ; Ahmed N2 ; Mosaddad SA3, 4, 5 ; Heboyan A3, 6, 7
Authors
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Authors Affiliations
  1. 1. Department of Dental Technology, COAMS, King Khalid University, Abha, Saudi Arabia
  2. 2. Department of Prosthodontics, Altamash Institute of Dental Medicine, Karachi, Pakistan
  3. 3. Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
  4. 4. Department of Conservative Dentistry and Bucofacial Prosthesis, Faculty of Odontology, Complutense University of Madrid, Madrid, Spain
  5. 5. Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia
  7. 7. Department of Prosthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Oral Biology Published:2024


Abstract

Objective: This study aimed to investigate the correlation between genetic factors and the occurrence and progression of temporomandibular disorders (TMDs) using a comprehensive review and meta-analysis. Design: A comprehensive search was conducted using the ScienceDirect, PubMed, Cochrane Library, Dimensions, and Emerald databases. A reviewer selected the study using modified PICO criteria, considering human subjects with TMDs, comparing different genetic factors among TMD and non-TMD patients, and reporting TMD signs and symptoms as outcomes. The methodological standards of the eligible papers were assessed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Non-randomized Experimental Investigations. Information was collected methodically and examined. Results: The electronic database search yielded 851 articles, 19 of which were included in this study. The data analysis showed a significant influence of genetic factors, such as polymorphisms and gene differences, on the development of TMD signs and symptoms, such as myofascial pain, chronic pain, and disc displacement. In addition, gene polymorphism significantly influenced TMD development, with an odds ratio of 2.46 (1.93–3.14) and p of 0.00001. Conclusions: Genetic factors significantly influenced TMD signs and symptoms, and genetic polymorphisms significantly influenced TMD onset and progression. Further research should be conducted in diverse settings with larger sample sizes to verify and validate these findings. © 2024 The Authors
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