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In Vitro Susceptibility Profiles of Eight Antifungal Drugs Against Clinical and Environmental Strains of Phaeoacremonium Publisher Pubmed



Badali H1 ; Khodavaisy S2, 3 ; Fakhim H4 ; De Hoog GS5 ; Meis JF6, 7 ; Chowdhary A8
Authors
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Authors Affiliations
  1. 1. Department of Medical Mycology and Parasitology, Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Department of Medical Parasitology and Mycology, Kurdistan University of Medical Sciences, Sanandaj, Iran
  3. 3. Department of Medical Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. SRC, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. CBS-KNAW Fungal Biodiversity Centre, Utrecht, Netherlands
  6. 6. Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands
  7. 7. Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, Netherlands
  8. 8. Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India

Source: Antimicrobial Agents and Chemotherapy Published:2015


Abstract

In vitro susceptibilities of a worldwide collection of molecularly identified Phaeoacremonium strains (n = 43) belonging to seven species and originating from human and environmental sources were determined for eight antifungal drugs. Voriconazole had the lowest geometric mean MIC (0.35 μg/ml), followed by posaconazole (0.37 μg/ml), amphotericin B (0.4 μg/ml), and isavuconazole (1.16 μg/ml). Caspofungin, anidulafungin, fluconazole, and itraconazole had no activity. Copyright © 2015, American Society for Microbiology. All Rights Reserved.