Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Kidney Publisher Pubmed



Oroojalian F1 ; Charbgoo F2 ; Hashemi M3 ; Amani A1, 4 ; Yazdianrobati R5 ; Mokhtarzadeh A6 ; Ramezani M7 ; Hamblin MR8, 9, 10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Advanced Sciences and Technologies, North Khorasan University of Medical Sciences, Bojnurd, Iran
  2. 2. DWI – Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, Aachen, 52056, Germany
  3. 3. Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, MA, United States
  9. 9. Department of Dermatology, Harvard Medical School, Boston, 02115, MA, United States
  10. 10. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa

Source: Journal of Controlled Release Published:2020


Abstract

The application of nanotechnology in medicine has the potential to make a great impact on human health, ranging from prevention to diagnosis and treatment of disease. The kidneys are the main organ of the human urinary system, responsible for filtering the blood, and concentrating metabolic waste into urine by means of the renal glomerulus. The glomerular filtration apparatus presents a barrier against therapeutic agents based on charge and/or molecular size. Therefore, drug delivery to the kidneys faces significant difficulties resulting in treatment failure in several renal disorders. Accordingly, different strategies have recently being explored for enhancing the delivery of therapeutic agents across the filtration barrier of the glomerulus. Nanosystems with different physicochemical properties, including size, shape, surface, charge, and possessing biological features such as high cellular internalization, low cytotoxicity, controllable pharmacokinetics and biodistribution, have shown promising results for renal therapy. Different types of nanoparticles (NPs) have been used to deliver drugs to the kidney. In this review, we discuss nanotechnology-based drug delivery approaches for acute kidney injury, chronic kidney disease, renal fibrosis, renovascular hypertension and kidney cancer. © 2020 Elsevier B.V.
Related Docs
View other Related Docs
1. Protein Corona Variation in Nanoparticles Revisited: A Dynamic Grouping Strategy, Colloids and Surfaces B: Biointerfaces (2019)
2. Bioavailability, Biodistribution, and Toxicity of Fluorescent Metal Nanoclusters, Luminescent Metal Nanoclusters: Synthesis# Characterization# and Applications (2022)
3. Nexus Between in Silico and in Vivo Models to Enhance Clinical Translation of Nanomedicine, Nano Today (2021)
4. New Insights Into Designing Hybrid Nanoparticles for Lung Cancer: Diagnosis and Treatment, Journal of Controlled Release (2019)
5. Tumor-Associated Macrophages, Nanomedicine and Imaging: The Axis of Success in the Future of Cancer Immunotherapy, Immunotherapy (2017)
6. Clinical Applications of Nanomedicine in Cancer Therapy, Drug Discovery Today (2020)
7. Exploring Innovative Strides in Radiolabeled Nanoparticle Progress for Multimodality Cancer Imaging and Theranostic Applications, Cancer Imaging (2024)
8. Antibiotic Resistance and Nanotechnology: A Narrative Review, Microbial Pathogenesis (2024)
Experts (# of related papers)
View all Related Experts
Fatemeh Atyabi (3)
Rassoul Dinarvand (2)
Other Related Docs
9. Ameliorative Impacts of Polymeric and Metallic Nanoparticles on Cisplatin-Induced Nephrotoxicity: A 2011–2022 Review, Journal of Nanobiotechnology (2022)
10. Nano-Delivery System Targeting to Cancer Stem Cell Cluster of Differentiation Biomarkers, Journal of Controlled Release (2017)
11. One-Pot Biosynthesis of Cds Quantum Dots Through in Vitro Regeneration of Hairy Roots of Rhaphanus Sativus L. and Their Apoptosis Effect on Mcf-7 and Ags Cancerous Human Cell Lines, Materials Research Express (2020)
12. The Quest for a Better Fight: How Can Nanomaterials Address the Current Therapeutic and Diagnostic Obstacles in the Fight Against Covid-19?, Journal of Drug Delivery Science and Technology (2022)
13. Potential of Nanoparticles and Nanopolymers in Treatment of Age-Associated Diseases, Advances in Natural Sciences: Nanoscience and Nanotechnology (2021)
14. Application of Nanoparticle Technology in the Treatment of Systemic Lupus Erythematous, Biomedicine and Pharmacotherapy (2016)
15. Polymeric Nanoparticles As a Promising Platform for Treating Triple-Negative Breast Cancer: Current Status and Future Perspectives, International Journal of Pharmaceutics (2024)
16. Stimuli-Responsive Mesoporous Silica Nps As Non-Viral Dual Sirna/Chemotherapy Carriers for Triple Negative Breast Cancer, Molecular Therapy Nucleic Acids (2017)