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Development of Poly (Mannitol Sebacate)/Poly (Lactic Acid) Nanofibrous Scaffolds With Potential Applications in Tissue Engineering Publisher Pubmed



Rahmani M1 ; Khani MM2, 3 ; Rabbani S4 ; Mashaghi A5, 6 ; Noorizadeh F7 ; Faridimajidi R1 ; Ghanbari H1, 4
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Medical Systems Biophysics and Bioengineering, Leiden Academic Centre for Drug Research, Faculty of Science, Leiden University, Leiden, Netherlands
  6. 6. Harvard Medical School, Harvard University, Boston, United States
  7. 7. Basir Eye Health Research Center, Tehran, Iran

Source: Materials Science and Engineering C Published:2020


Abstract

Developing a biomimetic substrate with intrinsic potential for cell attachment and growth has always been a tissue engineering challenge. In the present research, we successfully fabricated PMS:PLA nanofibrous scaffolds for the first time using electrospinning process by adjusting blending ratios, feed rates and polymer concentrations. A desirable composition was found when homogenous nanofibers with an average fiber diameter of 235 ± 38 nm were achieved at 10% w/v for PMS:PLA 60:40. The scaffolds were then characterized for their microstructure, mechanical strength and elasticity, degradation rate, porosity, wettability and cell/tissue compatibility. Mechanical analysis and degradation behavior of PMS:PLA nanofibrous scaffolds revealed appropriate elasticity, stiffness and strength, as well as degradation rate appropriate for soft tissues. Nitrogen adsorption-desorption analysis discovered that mesoporous nanofibers with enhanced specific surface area were fabricated. Further in vitro and in vivo biocompatibility evaluations revealed enhanced cytocompatibility, proliferation and tissue responses of PMS:PLA nanofibrous scaffolds with desirable cell-scaffold interactions. Moreover, PMS:PLA nanofibrous scaffolds exhibited negligible inflammatory responses with significantly thinner fibrotic capsule formation and minor infiltration of inflammatory cells compared to PLA nanofibers. These findings suggest that PMS/PLA nanofibrous scaffolds could be introduced as potential candidates with improved properties for soft tissue engineering applications. © 2020 Elsevier B.V.
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