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Androgen Deprivation Therapy Use and the Risk of Heart Failure in Patients With Prostate Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Khorram AA1 ; Pourasgharian R2 ; Shams AS3 ; Toufani S4 ; Mostafaei M2 ; Khademi R5 ; Daghayeghi R6 ; Valifard M7 ; Shahrokhi M8 ; Seyedipour S9 ; Deravi N2, 12 ; Naziri M10 ; Malek M11 ; Bashir F8
Authors
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Authors Affiliations
  1. 1. Urology Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Islamic Azad University of Tabriz, Tabriz, Iran
  4. 4. Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation
  7. 7. Student Research Committee, Nursing Department, Islamic Azad University, Jahrom, Iran
  8. 8. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Jiroft University of Medical Sciences, Jiroft, Iran
  10. 10. Students Research Committee, School of Medicine, Iran University of Medical Sciences, Hemat Highway, next to Milad Tower, Tehran, 14496-14535, Iran
  11. 11. Faculty of dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  12. 12. SBUMS, Arabi Ave, Daneshjoo Blvd, Tehran, Velenjak, 19839-63113, Iran

Source: BMC Cardiovascular Disorders Published:2024


Abstract

Background & Aim: We aimed in this study to investigate the relationship between Androgen Deprivation Therapy (ADT) use and the risk of heart failure in patients with prostate cancer. In this research, the negative or positive effects of ADT in the development of cardiovascular diseases or its exacerbation in people with prostate cancer have been investigated. Materials and methods: For this research, we reviewed articles from PubMed, Scopus, and Google Scholar databases until February 2024. We extracted and screened titles, abstracts, and full texts of related articles. The quality of studies was assessed and extracted and analyzed data. Result: A total of 9 studies comprising 189,045 patients were included in the meta-analysis, examining the association between androgen deprivation therapy (ADT) and heart failure. The overall pooled hazard ratio (HR) was 1.299 (95% CI: 1.003–1.595), indicating a significantly increased risk of heart failure with ADT. Subgroup analyses revealed that the risk was stronger in Asian populations (pooled HR = 1.545, 95% CI: 1.180–1.910) compared to North American populations (pooled HR = 0.779, 95% CI: 0.421–1.138). Conclusions: ADT has a significant relationship with cardiovascular disease. According to the analysis, ADT has increased the risk of heart failure in people with prostate cancer by 30%. © The Author(s) 2024.
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