One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors

One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors Publisher Pubmed

Niederwieser D^{1, 2, 3} ; Baldomero H⁴ ; Bazuaye N^{5, 6} ; Bupp C⁷ ; Chaudhri N^{8, 9} ; Corbacioglu S^{10, 11} ; Elhaddad A^{5, 12} ; Frutos C^{13, 14} ; Galeano S^{13, 15} ; Hamad N^{16, 17} ; Hamidieh AA^{8, 18} ; Hashmi S^{19, 20} ; Ho A^{21, 22} ; Horowitz MM²³ Show All Authors

Niederwieser D^{1, 2, 3}
Baldomero H⁴
Bazuaye N^{5, 6}
Bupp C⁷
Chaudhri N^{8, 9}
Corbacioglu S^{10, 11}
Elhaddad A^{5, 12}
Frutos C^{13, 14}
Galeano S^{13, 15}
Hamad N^{16, 17}
Hamidieh AA^{8, 18}
Hashmi S^{19, 20}
Ho A^{21, 22}
Horowitz MM²³
Iida M^{21, 24}
Jaimovich G^{13, 25}
Karduss A^{13, 26}
Kodera Y^{21, 24}
Kroger N^{10, 27}
De Latour RP^{10, 28}
Lee JW^{21, 29}
Martinezrolon J^{13, 30}
Pasquini MC²³
Passweg J^{10, 31}
Paulson K³²
Seber A^{13, 33}
Snowden JA^{10, 34}
Srivastava A^{21, 35}
Szer J^{16, 36}
Weisdorf D^{7, 37}
Worel N³⁸
Koh MBC^{39, 40}
Aljurf M^{8, 41}
Greinix H⁴²
Atsuta Y^{21, 43}
Saber W²³

Show Affiliations

1. University of Leipzig, Germany
2. Aichi Medical University School of Medicine, Nagakute, Japan
3. Lithuanian University of Health Sciences, Kaunas, Lithuania
4. The Worldwide Network of Blood and Marrow Transplantation (WBMT) Transplant Activity Survey Office, University Hospital, Basel, Switzerland
5. African Blood and Marrow Transplantation Group, AfBMT, Bern, Switzerland
6. University of Benin Teaching Hospital, Benin, Nigeria
7. CIBMTR (Center for International Blood and Marrow Transplant Research), National Marrow Donor Program/Be The Match, Minneapolis, MN, United States
8. The Eastern Mediterranean Blood and Marrow Transplant Group (EMBMT), King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
9. Oncology Center King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia
10. European Society for Blood and Marrow Transplantation (EBMT), Barcelona, Spain
11. Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany
12. Department of Pediatric Oncology, Stem Cell Transplantation Unit, Cairo University, Cairo, Egypt
13. Latin American Blood and Marrow Transplantation Group, LABMT, Bern, Switzerland
14. Cristobal Frutos, Instituto de Prevision Social, Asuncion, Paraguay
15. Sebastian Galeano, Hospital Britanico, Montevideo, Uruguay
16. Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), St. VincentÂ´s Hospital Sydney, Sydney, NSW, Australia
17. St. Vincent's Health Network, Kinghorn Cancer Center, Sydney, NSW, Australia
18. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
19. Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates
20. MAYO Clinic, Rochester, MN, United States
21. The Asia Pacific Blood and Marrow Transplant Group (APBMT), Aichi Medical University School of Medicine, Nagakute, Japan
22. Singapore General Hospital, Singapore, Singapore
23. CIBMTR, Medical College of Wisconsin, Milwaukee, WI, United States
24. Aichi Medical University School of Medicine, Deptartment of Promotion for Blood and Marrow Plantation, Nagakute, Japan
25. Fundacion Favaloro, Sanatorio Anchorena, ITAC, Buenos Aires, Argentina
26. Instituto de Cancerologia-Clinica Las Americas, Medellin, Colombia
27. Department of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany
28. Saint-Louis Hospital, 1 avenue Claude Vellefaux, Paris, France
29. Seoul St. Maryâ€™s Hospital, The Catholic University of Korea, Seoul, South Korea
30. FUNDALEU, Buenos Aires, Argentina
31. Klinik fur Hamatologie, Universitatsspital Basel, Basel, Switzerland
32. Cancercare Manitoba, the University of Manitoba and Cell Therapy Transplant Canada (CTTC), Winnipeg, MB, Canada
33. Pediatric Department, Hospital Samaritano, Sao Paulo, Brazil
34. Department of Hematology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
35. Christian Medical College, Vellore, India
36. Peter MacCallum Cancer Center, Royal Melbourne Hospital, Parkville, VIC, Australia
37. University of Minnesota, Minneapolis, MN, United States
38. Medical University of Vienna, Department of Blood Group Serology and Transfusion Medicine, Vienna, Austria
39. Infection and Immunity Clinical Academic Group, St Georgeâ€™s Hospital and Medical School, London, United Kingdom
40. Academic Cell Therapy Facility and Programme Health Sciences Authority, Singapore, Singapore
41. King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
42. Medical University of Graz, Division of Hematology, Graz, Austria
43. Japanese Data Center for Hematopoietic Cell Transplantation (JDCHCT), Nagoya, Japan

Source: Haematologica Published:2022

Abstract

The Worldwide Network of Blood and Marrow Transplantation (WBMT) pursues the mission of promoting hematopoietic cell transplantation (HCT) for instance by evaluating activities through member societies, national registries and individual centers. In 2016, 82,718 first HCT were reported by 1,662 HCT teams in 86 of the 195 World Health Organization member states representing a global increase of 6.2% in autologous HCT and 7.0% in allogeneic HCT and bringing the total to 1,298,897 procedures. Assuming a frequency of 84,000/year, 1.5 million HCT were performed by 2019 since 1957. Slightly more autologous (53.5%) than allogeneic and more related (53.6%) than unrelated HCT were reported. A remarkable increase was noted in haploidentical related HCT for leukemias and lymphoproliferative diseases, but even more in non-malignant diseases. Transplant rates (TR; HCT/10 million population) varied according to region reaching 560.8 in North America, 438.5 in Europe, 76.7 in Latin America, 53.6 in South East Asia/Western Pacific (SEA/WPR) and 27.8 in African/East Mediterranean (AFR/EMR). Interestingly, haploidentical TR amounted to 32% in SEA/WPR and 26% in Latin America, but only 14% in Europe and EMR and 4.9% in North America of all allogeneic HCT. HCT team density (teams/10 million population) was highest in Europe (7.7) followed by North America (6.0), SEA/WPR (1.9), Latin America (1.6) and AFR/EMR (0.4). HCT are increasing steadily worldwide with narrowing gaps between regions and greater increase in allogeneic compared to autologous activity. While related HCT is rising, largely due to increase in haploidentical HCT, unrelated HCT is plateauing and cord blood HCT is in decline. 2022 Ferrata Storti Foundation

2. Strategic Priorities for Hematopoietic Stem Cell Transplantation in the Emro Region, Hematology/ Oncology and Stem Cell Therapy (2023)

3. Introduction on Stem Cell Therapy and Regeneration, Comprehensive Hematology and Stem Cell Research: Volume 1-5 (2024)

4. Advances in Hematopoietic Stem Cell Transplantation in the Asia-Pacific Region: The Second Report From Apbmt 2005–2015, Bone Marrow Transplantation (2019)

5. Transplantation, Clinical Immunology (2022)

6. Prognostic Factors for Survival After Allogeneic Transplantation in Acute Myeloid Leukemia in Iran Using Censored Quantile Regression Model, Scientific Reports (2025)

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Style	Citing Format
MLA	Niederwieser D, et al.. "One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors." Haematologica, vol. 107, no. 5, 2022, pp. 1045-1053.
APA	Niederwieser D, Baldomero H, Bazuaye N, Bupp C, Chaudhri N, Corbacioglu S, Elhaddad A, Frutos C, Galeano S, Hamad N, Hamidieh AA, Hashmi S, Ho A, Horowitz MM, Iida M, Jaimovich G, Karduss A, Kodera Y, Kroger N, ... Saber W (2022). One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors. Haematologica, 107(5), 1045-1053.
Chicago	Niederwieser D, Baldomero H, Bazuaye N, Bupp C, Chaudhri N, Corbacioglu S, Elhaddad A, et al.. "One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors." Haematologica 107, no. 5 (2022): 1045-1053.
Harvard	Niederwieser D et al. (2022) 'One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors', Haematologica, 107(5), pp. 1045-1053.
Vancouver	Niederwieser D, Baldomero H, Bazuaye N, Bupp C, Chaudhri N, Corbacioglu S, et al.. One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors. Haematologica. 2022;107(5):1045-1053.
BibTex	@article{ author = {Niederwieser D and Baldomero H and Bazuaye N and Bupp C and Chaudhri N and Corbacioglu S and Elhaddad A and Frutos C and Galeano S and Hamad N and Hamidieh AA and Hashmi S and Ho A and Horowitz MM and Iida M and Jaimovich G and Karduss A and Kodera Y and Kroger N and De Latour RP and Lee JW and Martinezrolon J and Pasquini MC and Passweg J and Paulson K and Seber A and Snowden JA and Srivastava A and Szer J and Weisdorf D and Worel N and Koh MBC and Aljurf M and Greinix H and Atsuta Y and Saber W}, title = {One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors}, journal = {Haematologica}, volume = {107}, number = {5}, pages = {1045-1053}, year = {2022} }
RIS	TY - JOUR AU - Niederwieser D AU - Baldomero H AU - Bazuaye N AU - Bupp C AU - Chaudhri N AU - Corbacioglu S AU - Elhaddad A AU - Frutos C AU - Galeano S AU - Hamad N AU - Hamidieh AA AU - Hashmi S AU - Ho A AU - Horowitz MM AU - Iida M AU - Jaimovich G AU - Karduss A AU - Kodera Y AU - Kroger N AU - De Latour RP AU - Lee JW AU - Martinezrolon J AU - Pasquini MC AU - Passweg J AU - Paulson K AU - Seber A AU - Snowden JA AU - Srivastava A AU - Szer J AU - Weisdorf D AU - Worel N AU - Koh MBC AU - Aljurf M AU - Greinix H AU - Atsuta Y AU - Saber W TI - One and a Half Million Hematopoietic Stem Cell Transplants: Continuous and Differential Improvement in Worldwide Access With the Use of Non-Identical Family Donors JO - Haematologica VL - 107 IS - 5 SP - 1045 EP - 1053 PY - 2022 ER -

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