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Hotair But Not Anril Long Non-Coding Rna Contributes to the Pathogenesis of Multiple Sclerosis Publisher Pubmed



Pahlevan Kakhki M1 ; Nikravesh A2 ; Shirvani Farsani Z3 ; Sahraian MA4 ; Behmanesh M1
Authors
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Authors Affiliations
  1. 1. Faculty of Biological Sciences, Department of Genetics, Tarbiat Modares University, Tehran, Iran
  2. 2. Faculty of Medicine, Department of Medical Biotechnology & Molecular Sciences, North Khorasan University of Medical Sciences, Bojnurd, Iran
  3. 3. Faculty of Biological Sciences and Technology, Department of Cellular and Molecular Biology, Shahid Beheshti G.C., Tehran, Iran
  4. 4. MS Research Centre, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Immunology Published:2018


Abstract

Studies have revealed that dysregulation in gene expression is one of the main aspects of multiple sclerosis (MS) pathogenesis. Although the molecular pathways underlying the immunomodulatory role of vitamin D (VD) in MS is not completely elucidated, VD has more recently become a topic of interest in immune regulation and is widely administered to patients with MS as an immunomodulatory supplement. Long non-coding RNAs (lncRNAs) are known to play important roles in regulation of gene expression via different mechanisms. Given that VD-related genes are regulated by epigenetic mechanisms, here we aimed to evaluate the role of VD in combination with HOTAIR and ANRIL lncRNAs using in vivo, in vitro and in silico experiments in MS pathogenesis. Our data revealed that HOTAIR but not ANRIL lncRNA is probably involved in the pathogenesis of MS and experimental autoimmune encephalomyelitis through an unclear mechanism and it seems that by affecting the expression, inflammation and VD can influence HOTAIR-related mechanisms, which require further study. © 2017 John Wiley & Sons Ltd
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