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The Emerging Role of Lncrnas in Multiple Sclerosis Publisher Pubmed



Ghaderian S1 ; Shomali N2, 3 ; Behravesh S1 ; Danbaran GR1 ; Hemmatzadeh M2, 3 ; Aslani S4 ; Jadidiniaragh F5, 6 ; Hosseinzadeh R4 ; Torkamandi S7 ; Mohammadi H8, 9
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Medical Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  8. 8. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  9. 9. Department of Immunology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Source: Journal of Neuroimmunology Published:2020


Abstract

Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS) with various clinical manifestations. The characteristic of MS is that myelin is attacked by the body's immune system and increases the electrical capacity of axons, and is the primary pathophysiological mechanism of the transmission block. Studies have shown that epigenetic factors participate in the development of MS. LncRNAs are highly abundant and heterogeneous linear RNA transcripts with lengths exceeding 200 nucleotides and no protein-coding potential. Currently, pieces of evidence have demonstrated that lncRNAs have fundamental actions in multiple cellular pathways, including immune system regulation, epithelial-mesenchymal transition (EMT), cancer cell growth and metastasis, cellular homeostasis, and embryo development. It has been demonstrated that epigenetic mechanisms have an abundant role in the pathogenesis of MS in which the role of lncRNAs as epigenetic regulatory molecules in molecular processes has been proven. In this paper, we have focused on the correlation between MS and lncRNAs, the role of lncRNA in the pathogenesis of the disease, and the diagnostic and prognostic potential of lncRNA in MS. © 2020 Elsevier B.V.
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