Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women

Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women Publisher Pubmed

Setayesh L¹ ; Amini A² ; Bagheri R³ ; Moradi N⁴ ; Yarizadeh H¹ ; Asbaghi O⁵ ; Casazza K⁶ ; Yekaninejad MS⁷ ; Wong A⁸ ; Suzuki K⁹ ; Mirzaei K¹

Show Affiliations

1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
2. Department of Mechanical Engineering, Australian College of Kuwait, Safat, 13015, Kuwait
3. Department of Exercise Physiology, University of Isfahan, Isfahan, 8174673441, Iran
4. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, 6617713446, Iran
5. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 1416753955, Iran
6. Marieb College of Health and Human Services, Florida Gulf Coast University, Fort Myers, 33965, FL, United States
7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
8. Department of Health and Human Performance, Marymount University, Arlington, 22207, VA, United States
9. Faculty of Sport Sciences, Waseda University, Tokyo, 2-579-15, Japan

Source: Nutrients Published:2021

Abstract

(1) Background: Observational studies have established that vitamin D-binding protein (DBP) and 25-hydroxyvitamin D3 (25(OH)D) concentrations are the major factors affecting the bioavailability of 25(OH)D. It has also been shown that poor 25(OH)D bioavailability elevates the risk of obesity and its related cardio-metabolic disorders. However, the relationship between 25(OH)D and DBP concentrations with cardio-metabolic risk factors in overweight and obese cohorts has not been established. Consequently, we evaluated the association between DBP and 25(OH)D concentrations with lipid profile, blood pressure (BP), and body composition in overweight and obese women. (2) Methods: In this cross-sectional study of 236 overweight and obese women, DBP and 25(OH)D concentrations were measured using an enzyme-linked immunosorbent assay. Body composition was assessed via bioelectrical impedance analysis. Lipid profile and BP were assessed by an auto-analyzer and digital BP monitor, respectively. The associations were examined by multivariate logistic regression. (3) Results: The indicated showed an inverse relationship between DBP and high-density lipoprotein (HDL) (p = 0.010) concentrations (where individuals with higher DBP had lower HDL) which, after adjusting for possible cofounders, remained significant (p = 0.006). Moreover, DBP concentration was positively associated with fat mass index (FMI) after adjustment (p = 0.022). No significant relationships were observed among 25(OH)D and target variables. (4) Conclusions: In conclusion, lower concentrations of HDL and higher values of FMI are associated with higher concentrations of DBP in overweight and obese women. These findings present novel awareness regarding the association of DBP with some metabolic and body composition variables in overweight and obese women. However, a two-way causal relationship between DBP and target variables should be considered. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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Khadijeh Mirzaei (5)

Mir Saeed Yekaninejad (4)

Style	Citing Format
MLA	Setayesh L, et al.. "Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women." Nutrients, vol. 13, no. 9, 2021, pp. -.
APA	Setayesh L, Amini A, Bagheri R, Moradi N, Yarizadeh H, Asbaghi O, Casazza K, Yekaninejad MS, Wong A, Suzuki K, Mirzaei K (2021). Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women. Nutrients, 13(9), -.
Chicago	Setayesh L, Amini A, Bagheri R, Moradi N, Yarizadeh H, Asbaghi O, Casazza K, et al.. "Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women." Nutrients 13, no. 9 (2021): -.
Harvard	Setayesh L et al. (2021) 'Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women', Nutrients, 13(9), pp. -.
Vancouver	Setayesh L, Amini A, Bagheri R, Moradi N, Yarizadeh H, Asbaghi O, et al.. Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women. Nutrients. 2021;13(9):-.
BibTex	@article{ author = {Setayesh L and Amini A and Bagheri R and Moradi N and Yarizadeh H and Asbaghi O and Casazza K and Yekaninejad MS and Wong A and Suzuki K and Mirzaei K}, title = {Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women}, journal = {Nutrients}, volume = {13}, number = {9}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Setayesh L AU - Amini A AU - Bagheri R AU - Moradi N AU - Yarizadeh H AU - Asbaghi O AU - Casazza K AU - Yekaninejad MS AU - Wong A AU - Suzuki K AU - Mirzaei K TI - Elevated Plasma Concentrations of Vitamin D-Binding Protein Are Associated With Lower High-Density Lipoprotein and Higher Fat Mass Index in Overweight and Obese Women JO - Nutrients VL - 13 IS - 9 SP - EP - PY - 2021 ER -

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