Tehran University of Medical Sciences

Science Communicator Platform

Share By
Autophagy in Spinal Cord Injury: A Double- Edged Sword in Preclinical Studies of Synthetic and Natural Compounds Publisher



T Mokhtari TAHMINEH ; F Majidi FARZANEH ; F Sheikhbahaei FATEMEH ; Pb Shahreza Parvaneh BEHI ; Mp Poorhassan Mahnaz POUR
Authors

Source: Published:2025


Abstract

Autophagy is a crucial cellular process involved in spinal cord injury (SCI) patho-physiology. It can protect neural tissues by removing damaged cellular components, thereby promoting recovery. However, excessive autophagy may lead to neuronal apoptosis, inflammation, and disrupted cellular balance. This chapter explores the balance between autophagic activity and cellular health, emphasizing the need for precise regulation to harness autophagy's therapeutic potential. Recent studies highlight how autophagy interacts with mitochondrial dysfunction, reactive oxygen species, and inflammatory responses in SCI. Moreover, it discusses how natural compounds and nutraceuticals can modulate autophagy, offering promising strategies for managing consequences of SCI. Understanding autophagy is vital for advancing therapeutic interventions in SCI. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Autophagy, Its Mechanisms and Regulation: Implications in Neurodegenerative Diseases, Ageing Research Reviews (2017)
2. The Role of Autophagy in Cancer: From Molecular Mechanism to Therapeutic Window, Frontiers in Immunology (2025)
3. Regulation of Autophagy by Polyphenols: Paving the Road for Treatment of Neurodegeneration, Biotechnology Advances (2018)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Dehpour (2)
Seyed Abdolhussein Tabatabaie (1)
Other Related Docs
4. Autophagy in Rheumatoid Arthritis: Molecular Mechanisms, Diagnostic Biomarkers, and Emerging Therapeutic Strategies, Inflammation (2026)
5. Autophagy Role As a Double-Edged Sword in Anesthesiology and Critical Care, Journal of Cellular and Molecular Anesthesia (2021)
6. Novel Therapeutic Strategies for Stroke: The Role of Autophagy, Critical Reviews in Clinical Laboratory Sciences (2019)
7. Autophagy: A Challengeable Paradox in Cancer Treatment, Cancer Medicine (2023)
8. Autophagy Modulation and Cancer Combination Therapy: A Smart Approach in Cancer Therapy, Cancer Treatment and Research Communications (2022)
9. The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (Aml)?, International Journal of Hematology-Oncology and Stem Cell Research (2022)
10. Autophagy and Neuropsychiatric Disorders: Unraveling Molecular Mechanisms and Signaling Pathways, CNS and Neurological Disorders - Drug Targets (2025)
11. The Role and Function of Autophagy Through Signaling and Pathogenetic Pathways and Lncrnas in Ovarian Cancer, Pathology Research and Practice (2024)
12. Phytochemicals As Potent Modulators of Autophagy for Cancer Therapy, Cancer Letters (2018)
13. Role of Autophagy in the Pathogenesis of Rheumatoid Arthritis: Latest Evidence and Therapeutic Approaches, Life Sciences (2020)
14. Autophagy Induced by Metabolic Processes Leads to Solid Tumor Cell Metastatic Dormancy and Recurrence, Medical Oncology (2025)
15. Micrornas Regulating Autophagy: Opportunities in Treating Neurodegenerative Diseases, Frontiers in Neuroscience (2024)
16. Arsenic Trioxide Induction Autophagy in Human Acute Promyelocytic Leukemia, Koomesh (2018)
17. Autophagy Pathways in Major Depressive Disorder, (2025)
18. The Role of Autophagy in Controlling Sars-Cov-2 Infection: An Overview on Virophagy-Mediated Molecular Drug Targets, Cell Biology International (2021)
19. Interplay Between Oxidative Stress and Autophagy Function and Its Role in Inflammatory Cytokine Expression Induced by Palmitate in Skeletal Muscle Cells, Cytokine (2020)
20. Revisiting the Role of Autophagy in Cardiac Differentiation: A Comprehensive Review of Interplay With Other Signaling Pathways, Genes (2023)