Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies

Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies Publisher Pubmed

Amirifar P^{1, 2} ; Yazdani R^{1, 3} ; Azizi G⁴ ; Ranjouri MR¹ ; Durandy A⁵ ; Plebani A⁶ ; Lougaris V⁶ ; Hammarstrom L^{7, 8} ; Aghamohammadi A¹ ; Abolhassani H^{1, 7, 8}

Show Affiliations

1. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
4. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
5. Human Lymphohematopoiesis Laboratory, Institut Imagine, Inserm U1163, Paris Descartes Sorbonne, Paris Cite University, Paris, France
6. Pediatrics Clinic and A. Nocivelli Institute for Molecular Medicine, Department of Clinical and Experimental Sciences, University of Brescia, ASST Spedali Civili of Brescia, Brescia, Italy
7. Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden
8. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden

Source: Pediatric Allergy and Immunology Published:2021

Abstract

Predominantly antibody deficiencies (PADs) encompass a heterogeneous group of disorders characterized by low immunoglobulin serum levels in the presence or absence of peripheral B cells. Clinical presentation of affected patients may include recurrent respiratory and gastrointestinal infections, invasive infections, autoimmune manifestations, allergic reactions, lymphoproliferation, and increased susceptibility to malignant transformation. In the last decades, several genetic alterations affecting B-cell development/maturation have been identified as causative of several forms of PADs, adding important information on the genetic background of PADs, which in turn should lead to a better understanding of these disorders and precise clinical management of affected patients. This review aimed to present a comprehensive overview of the known and potentially involved molecules in the etiology of PADs to elucidate the pathogenesis of these disorders and eventually offer a better prognosis for affected patients. © 2021 The Authors. Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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Style	Citing Format
MLA	Amirifar P, et al.. "Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies." Pediatric Allergy and Immunology, vol. 32, no. 8, 2021, pp. 1601-1615.
APA	Amirifar P, Yazdani R, Azizi G, Ranjouri MR, Durandy A, Plebani A, Lougaris V, Hammarstrom L, Aghamohammadi A, Abolhassani H (2021). Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies. Pediatric Allergy and Immunology, 32(8), 1601-1615.
Chicago	Amirifar P, Yazdani R, Azizi G, Ranjouri MR, Durandy A, Plebani A, Lougaris V, Hammarstrom L, Aghamohammadi A, Abolhassani H. "Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies." Pediatric Allergy and Immunology 32, no. 8 (2021): 1601-1615.
Harvard	Amirifar P et al. (2021) 'Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies', Pediatric Allergy and Immunology, 32(8), pp. 1601-1615.
Vancouver	Amirifar P, Yazdani R, Azizi G, Ranjouri MR, Durandy A, Plebani A, et al.. Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies. Pediatric Allergy and Immunology. 2021;32(8):1601-1615.
BibTex	@article{ author = {Amirifar P and Yazdani R and Azizi G and Ranjouri MR and Durandy A and Plebani A and Lougaris V and Hammarstrom L and Aghamohammadi A and Abolhassani H}, title = {Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies}, journal = {Pediatric Allergy and Immunology}, volume = {32}, number = {8}, pages = {1601-1615}, year = {2021} }
RIS	TY - JOUR AU - Amirifar P AU - Yazdani R AU - Azizi G AU - Ranjouri MR AU - Durandy A AU - Plebani A AU - Lougaris V AU - Hammarstrom L AU - Aghamohammadi A AU - Abolhassani H TI - Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies JO - Pediatric Allergy and Immunology VL - 32 IS - 8 SP - 1601 EP - 1615 PY - 2021 ER -

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