In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration

In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration Publisher Pubmed

Ebrahimi M¹ ; Ai J¹ ; Biazar E² ; Ebrahimibarough S¹ ; Khojasteh A³ ; Yazdankhah M⁴ ; Sharifi S⁵ ; Ai A⁶ ; Heidarikeshel S⁷

Show Affiliations

1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States
5. Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Sharekord University, Sharekord, Iran
6. Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran
7. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2018

Abstract

A nanofibrous silk nerve conduit has been evaluated for its efficiency based on the promotion of peripheral nerve regeneration in rats. The designed tubes with or without Schwann cells were implanted into a 10 mm gap in the sciatic nerves of the rats. Four months after the surgery, the regenerated nerves were monitored and evaluated by macroscopic assessments and histology. The results demonstrated that the nanofibrous grafts, especially in the presence of Schwann cells, enabled reconstruction of the rat sciatic nerve trunk with a restoration of nerve continuity and formation of nerve fibres with myelination. Histological data demonstrated the presence of Schwann and glial cells in regenerated nerves. This study strongly supports the feasibility of using artificial nerve grafts for peripheral nerve regeneration by bridging large defects in a rat model. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Ebrahimi M, et al.. "In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration." Artificial Cells# Nanomedicine and Biotechnology, vol. 46, no. sup1, 2018, pp. 394-401.
APA	Ebrahimi M, Ai J, Biazar E, Ebrahimibarough S, Khojasteh A, Yazdankhah M, Sharifi S, Ai A, Heidarikeshel S (2018). In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration. Artificial Cells# Nanomedicine and Biotechnology, 46(sup1), 394-401.
Chicago	Ebrahimi M, Ai J, Biazar E, Ebrahimibarough S, Khojasteh A, Yazdankhah M, Sharifi S, Ai A, Heidarikeshel S. "In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration." Artificial Cells# Nanomedicine and Biotechnology 46, no. sup1 (2018): 394-401.
Harvard	Ebrahimi M et al. (2018) 'In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration', Artificial Cells# Nanomedicine and Biotechnology, 46(sup1), pp. 394-401.
Vancouver	Ebrahimi M, Ai J, Biazar E, Ebrahimibarough S, Khojasteh A, Yazdankhah M, et al.. In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration. Artificial Cells# Nanomedicine and Biotechnology. 2018;46(sup1):394-401.
BibTex	@article{ author = {Ebrahimi M and Ai J and Biazar E and Ebrahimibarough S and Khojasteh A and Yazdankhah M and Sharifi S and Ai A and Heidarikeshel S}, title = {In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {46}, number = {sup1}, pages = {394-401}, year = {2018} }
RIS	TY - JOUR AU - Ebrahimi M AU - Ai J AU - Biazar E AU - Ebrahimibarough S AU - Khojasteh A AU - Yazdankhah M AU - Sharifi S AU - Ai A AU - Heidarikeshel S TI - In Vivo Assessment of a Nanofibrous Silk Tube As Nerve Guide for Sciatic Nerve Regeneration JO - Artificial Cells# Nanomedicine and Biotechnology VL - 46 IS - sup1 SP - 394 EP - 401 PY - 2018 ER -

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