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Recent Developments in Arylation of N-Nucleophiles Via Chan-Lam Reaction: Up-Dates From 2012 Onwards Publisher Pubmed



Abedinifar F1 ; Mahdavi M1 ; Rezaei EB1 ; Asadi M1 ; Larijani B1
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Organic Synthesis Published:2022


Abstract

''Chan-Evans-Lam'' (CEL) reaction is the copper-mediated cross-coupling of N-nucleophiles with boronic acids that was independently reported in 1998 by Chan, Evans, and Lam for the first time. This reaction is accom-plished at room temperature with a remarkably wide range of nucleophiles. In the recent decade, it has been particu-larly attractive as a convenient method for constructing the various C–N bonds in organic synthesis. Therefore, a comprehensive survey through all reported process was crucial. In this review, we summarized research progress about N-Arylation, based on the type of N-nucleophile involved in this reaction and catalysts from 2012 onwards. © 2022 Bentham Science Publishers.