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Transition Metal-Catalyzed Cross-Coupling Reactions of N-Aryl-2-Aminopyridines Publisher



Doraghi F1 ; Rezainia L2 ; Morshedsolouk MH1, 2 ; Navid H2 ; Larijani B1 ; Mahdavi M1
Authors

Source: RSC Advances Published:2025


Abstract

Due to the presence of the pyridyl directing group, N-aryl-2-aminopyridines can quickly form stable complexes with metals, leading to cyclization and functionalization reactions. A large number of N-heterocycles and nitrogen-based molecules can be easily constructed via this direct and atom-economical cross-coupling strategy. In this review, we have highlighted the transformations of N-aryl-2aminopyridines in the presence of various transition metal catalysts, such as palladium, rhodium, iridium, ruthenium, cobalt and copper. © 2025 The Author(s)
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