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N-Arylation Reaction of 2-Amino-N-Phenylbenzamide With Phenyl Boronic Acid Via Chan–Evans–Lam (Cel) Type Reaction Using Cu@Phen@Mgo Catalyst Publisher



Ghasemi N1 ; Moazzam A2 ; Bahadorikhalili S3 ; Yavari A2 ; Hosseini S2 ; Sayahi MH4 ; Larijani B2 ; Hamedifar H5 ; Ansari S5 ; Mahdavi M2
Authors
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Authors Affiliations
  1. 1. Department of Chemistry Tehran North Branch, Islamic Azad University, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Centre, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Electronic Engineering, Universitat Rovira I Virgili, Tarragona, 43007, Spain
  4. 4. Department of Chemistry, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran, Iran
  5. 5. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: Catalysis Letters Published:2023


Abstract

Cu@Phen@MGO catalyst was synthesized by the functionalization of magnetic graphene oxide (MGO) with phenanthroline type ligand. The catalyst was characterized by several characterization methods and used as an effective magnetic heterogeneous nanocatalyst for the N-arylation of 2-amino-N-phenylbenzamide. Cu@Phen@MGO catalyst showed very good efficiency in base-free Chan–Evans–Lam coupling of arylboronic acid with 2-amino-N-phenylbenzamide at room temperature. The products were obtained in high isolated yields. Easy recoverability of the catalyst by an external magnet, reusability up to six runs without significant loss of activity, and its well stability during the reaction are among the other highlights of this catalyst. Graphical Abstract: [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.