Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females

Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females Publisher Pubmed

Setayesh L^{1, 2} ; Casazza K³ ; Moradi N⁴ ; Mehranfar S¹ ; Yarizadeh H¹ ; Amini A⁵ ; Yekaninejad MS⁶ ; Mirzaei K¹

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1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box: 14155-6117, Tehran, Iran
2. Students Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
3. Marieb College of Health and Human Services, Florida Gulf Coast University, Florida, FL, United States
4. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
5. Department of Mechanical Engineering, Australian College of Kuwait, Safat, 13015, Kuwait
6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: BMC Research Notes Published:2021

Abstract

Objective: Equivocal association the contribution of 25-hydroxyvitamin D (25(OH)D) and the well-accepted role of vitamin D-binding protein (VDBP) on bioavailability of 25(OH)D or its independent roles, has led to possible association of the VDBP in glucose metabolism. This study was conducted to evaluate the relationships among 25(OH)D, VDBP, glucose/insulin metabolism and homeostatic model assessment (HOMA-IR). Blood samples were collected from 236 obese and overweight women. VDBP and 25(OH)D levels, and biochemical parameters were measured using an enzyme-linked immunosorbent assay (ELISA). An impedance fat analyzer was utilized to acquire the body composition. Results: Using the multivariate linear regression, a reverse relationship was observed between VDBP and (HOMA-IR), such that women with higher VDBP displayed lower insulin resistance. The relationship was independent of age, body mass index, standardized energy intake and physical activity (p = 0.00). No significant relationship between 25(OH)D levels, FBS, body composition or insulin resistance were observed (p > 0.2). Current study observed that higher level of VDBP may be associated with lower levels of insulin and HOMA-IR, thus the evaluation of VDBP in diverse population groups seems to have significant clinical value in evaluating the prevalence of DM or early stage of glucose intolerance. © 2021, The Author(s).

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Khadijeh Mirzaei (3)

Sakineh Shab-Bidar (2)

Style	Citing Format
MLA	Setayesh L, et al.. "Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females." BMC Research Notes, vol. 14, no. 1, 2021, pp. -.
APA	Setayesh L, Casazza K, Moradi N, Mehranfar S, Yarizadeh H, Amini A, Yekaninejad MS, Mirzaei K (2021). Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females. BMC Research Notes, 14(1), -.
Chicago	Setayesh L, Casazza K, Moradi N, Mehranfar S, Yarizadeh H, Amini A, Yekaninejad MS, Mirzaei K. "Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females." BMC Research Notes 14, no. 1 (2021): -.
Harvard	Setayesh L et al. (2021) 'Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females', BMC Research Notes, 14(1), pp. -.
Vancouver	Setayesh L, Casazza K, Moradi N, Mehranfar S, Yarizadeh H, Amini A, et al.. Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females. BMC Research Notes. 2021;14(1):-.
BibTex	@article{ author = {Setayesh L and Casazza K and Moradi N and Mehranfar S and Yarizadeh H and Amini A and Yekaninejad MS and Mirzaei K}, title = {Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females}, journal = {BMC Research Notes}, volume = {14}, number = {1}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Setayesh L AU - Casazza K AU - Moradi N AU - Mehranfar S AU - Yarizadeh H AU - Amini A AU - Yekaninejad MS AU - Mirzaei K TI - Association of Vitamin D-Binding Protein and Vitamin D3 With Insulin and Homeostatic Model Assessment (Homa-Ir) in Overweight and Obese Females JO - BMC Research Notes VL - 14 IS - 1 SP - EP - PY - 2021 ER -

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