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Embryonic Stem Cells and Infertility Publisher Pubmed



Lorzadeh N1 ; Kazemirad N2
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Authors Affiliations
  1. 1. Faculty of Medicine, Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Lorestan Province, Khorramabad, A81, Iran
  2. 2. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: American Journal of Perinatology Published:2018


Abstract

Embryonic stem cells (ESCs) have the ability to differentiate into several cell lineages and self-renew. Through a spontaneous process, ESCs can differentiate into germ cells of various stages, partly due to their self-renewal ability and their microenvironment culture. Human and mouse ESC differentiation into putative primordial germ cells (PGCs) has been demonstrated by several studies; in fact, derivation of functional mouse male gametes has also been reported. However, the exact underlying mechanisms are yet to be understood properly, and as such clinical applications of ESC-derived PGC remains controversial. Nonetheless, this technique can still serve as a potential treatment option for infertility. This review centers on the available reports on the possible application of ESC for infertility treatment. © 2018 Georg Thieme Verlag. All rights reserved.
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