Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Smart Bomb As1411 Aptamer-Functionalized/Pamam Dendrimer Nanocarriers for Targeted Drug Delivery in the Treatment of Gastric Cancer Publisher Pubmed



Barzegar Behrooz A1 ; Nabavizadeh F1 ; Adiban J2 ; Shafiee Ardestani M3 ; Vahabpour R4 ; Aghasadeghi MR5 ; Sohanaki H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Biomedical Engineering and Medical physics, Department of Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Medical Lab Technology Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran

Source: Clinical and Experimental Pharmacology and Physiology Published:2017


Abstract

Chemotherapy, a conventional method assessed in recent oncology studies, poses numerous problems in the clinical environment. To overcome the problems inherent in chemotherapy, an intelligent drug delivery system has come to the forefront of cancer therapeutics. In this study, we designed a dendrimer-based pharmaceutical system together with a single-stranded AS1411 aptamer (APTAS 1411) as a therapeutic strategy. The polyamidoamine (PAMAM)-polyethylene glycol (PEG) complex was then conjugated with the AS1411 aptamer and confirmed by atomic-force microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR).In this study, we show that the conjugated PAMAM-PEG-APTAS 1411complex dramatically increased PAMAM-PEG-5-FU uptake by MKN45 gastric cancer cells. We also demonstrated both the stability of the nanoparticle-5-FU-APTAS 1411 complex, by thin layer chromatography (TLC), and an increase in 5-fluorouracil (5-FU) accumulation in the vicinity of cancerous tumors. This smart drug delivery system is capable of effectively transferring 5-FU to MKN45 gastric cancer cells in consistent and without toxic effects. © 2016 John Wiley & Sons Australia, Ltd
Related Docs
1. Study of Regulatory Promoter Polymorphism (-248 G>A) of Bax Gene in Patients With Gastric Cancer in the Northern Provinces of Iran, Gastroenterology and Hepatology from Bed to Bench (2016)
2. Synthesis and Evaluation of a Glutamic Acid-Modified Hpamam Complex As a Promising Versatile Gene Carrier, Journal of Drug Targeting (2016)
3. Assessment of Hydrogeochemical Characteristics and Quality of Groundwater Resources in Relation to Risk of Gastric Cancer: Comparative Analysis of High- and Low-Risk Areas in Iran, Environmental Geochemistry and Health (2021)
4. Synthesis of a Novel Pegdga-Coated Hpamam Complex As an Efficient and Biocompatible Gene Delivery Vector: An in Vitro and in Vivo Study, Drug Delivery (2016)
5. Environmental Etiology of Gastric Cancer in Iran: A Systematic Review Focusing on Drinking Water, Soil, Food, Radiation, and Geographical Conditions, Environmental Science and Pollution Research (2019)
Experts (# of related papers)
View all Related Experts
Reza Shirkoohi (2)
Hossein Poustchi (2)