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Recent Advances in Mesenchymal Stem/Stromal Cells (Mscs)-Based Approaches for Osteoarthritis (Oa) Therapy Publisher Pubmed



Hassanzadeh A1 ; Vousooghi N1 ; Rahimnia R2 ; Razeghian E3 ; Rajaeian S1 ; Seyhoun I1 ; Sharif S1, 4 ; Verdi J1, 4
Authors
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Authors Affiliations
  1. 1. Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Division of Human Genetics, Department of Medical Biotechnology, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran
  4. 4. Research Center for War-affected People, Tehran University of Medical Sciences, Tehran, Iran

Source: Cell Biology International Published:2023


Abstract

Recently, mesenchymal stem/stromal cells (MSCs) transplantation has been introduced as a promising option to support cartilage structure and improve its function in preclinical models and patients suffering from osteoarthritis (OA). MSCs strongly provoke their preferred influence in vivo by inhibiting the inflammatory responses and applying immunomodulation by releasing anti-inflammatory mediators such as transforming growth factor-β and interleukin-10. Such mediators downregulate fibroblast-like synoviocytes growth and migration, leading to chondroprotection. Furthermore, improving the chondrocyte proliferation and extracellular matrix hemostasis in addition to the suppression of the matrix metalloproteinases activities can support cartilage tissue organization. In this light, various published results have demonstrated that MSCs therapy can considerably decrease pain and restore knee function in OA patients. In the current review, we have concentrated on recent advances in MSCs-based therapeutics to elicit both chondrogenic and chondroprotective impacts in OA patients, focusing on the last decade in vivo results. © 2023 International Federation for Cell Biology.
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