Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
New Insights Into Cartilage Tissue Engineering: Improvement of Tissue-Scaffold Integration to Enhance Cartilage Regeneration Publisher Pubmed



Jelodari S1, 2 ; Ebrahimi Sadrabadi A3 ; Zarei F3 ; Jahangir S4 ; Azami M1 ; Sheykhhasan M5, 6 ; Hosseini S2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Acecr, Tehran, Iran
  3. 3. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Acecr, Tehran, Iran
  4. 4. Ao Research Institute Davos, Davos, Switzerland
  5. 5. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Department of Mesenchymal Stem Cells, Academic Center for Education Culture and Research (ACECR), Qom Branch, Qom, Iran

Source: BioMed Research International Published:2022


Abstract

Distinctive characteristics of articular cartilage such as avascularity and low chondrocyte conversion rate present numerous challenges for orthopedists. Tissue engineering is a novel approach that ameliorates the regeneration process by exploiting the potential of cells, biodegradable materials, and growth factors. However, problems exist with the use of tissue-engineered construct, the most important of which is scaffold-cartilage integration. Recently, many attempts have been made to address this challenge via manipulation of cellular, material, and biomolecular composition of engineered tissue. Hence, in this review, we highlight strategies that facilitate cartilage-scaffold integration. Recent advances in where efficient integration between a scaffold and native cartilage could be achieved are emphasized, in addition to the positive aspects and remaining problems that will drive future research. © 2022 Sahar Jelodari et al.
Other Related Docs
13. 3D Printing in Oral & Maxillofacial Surgery, 3D Printing in Oral & Maxillofacial Surgery (2021)
19. Portable Hand-Held Bioprinters Promote in Situ Tissue Regeneration, Bioengineering and Translational Medicine (2022)
21. Advancement of Organoid Technology in Regenerative Medicine, Regenerative Engineering and Translational Medicine (2023)