Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process

Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process Publisher Pubmed

Rashti A¹ ; Yahyaei H² ; Firoozi S³ ; Ramezani S⁴ ; Rahiminejad A¹ ; Karimi R⁵ ; Farzaneh K⁶ ; Mohseni M² ; Ghanbari H^{1, 6, 7}

Show Affiliations

1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran
3. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
4. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
7. Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Materials Science and Engineering C Published:2016

Abstract

Due to high biocompatibility, polyurethane has found many applications, particularly in development of biomedical devices. A new nanocomposite based on thermoset polyurethane and silica nanoparticles was synthesized using sol-gel method. Sol-gel process was fulfilled in two acidic and basic conditions by using tetraethylorthosilicate (TEOS) and trimethoxyisocyanatesilane as precursors. The hybrid films characterized for mechanical and surface properties using tensile strength, contact angle, ATR-FTIR and scanning electron microscopy. Biocompatibility and cytotoxicity of the hybrids were assessed using standard MTT, LDH and TUNEL assays. The results revealed that incorporation of silica nanoparticles was significantly improved tensile strength and mechanical properties of the hybrids. Based on the contact angle results, silica nanoparticles increased hydrophilicity of the hybrids. Biocompatibility by using human lung epithelial cell line (MRC-5) demonstrated that the hybrids were significantly less cytotoxic compared to pristine polymer as tested by MTT and LDH assays. TUNEL assay revealed no signs of apoptosis in all tested samples. The results of this study demonstrated that incorporation of silica nanoparticles into polyurethane lead to the enhancement of biocompatibility, indicating that these hybrids could potentially be used in biomedical field in particular as a new coating for medical implants. © 2016

Experts (# of related papers)

Hossein Ghanbari (1)

Style	Citing Format
MLA	Rashti A, et al.. "Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process." Materials Science and Engineering C, vol. 69, no. , 2016, pp. 1248-1255.
APA	Rashti A, Yahyaei H, Firoozi S, Ramezani S, Rahiminejad A, Karimi R, Farzaneh K, Mohseni M, Ghanbari H (2016). Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process. Materials Science and Engineering C, 69(), 1248-1255.
Chicago	Rashti A, Yahyaei H, Firoozi S, Ramezani S, Rahiminejad A, Karimi R, Farzaneh K, Mohseni M, Ghanbari H. "Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process." Materials Science and Engineering C 69, no. (2016): 1248-1255.
Harvard	Rashti A et al. (2016) 'Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process', Materials Science and Engineering C, 69(), pp. 1248-1255.
Vancouver	Rashti A, Yahyaei H, Firoozi S, Ramezani S, Rahiminejad A, Karimi R, et al.. Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process. Materials Science and Engineering C. 2016;69():1248-1255.
BibTex	@article{ author = {Rashti A and Yahyaei H and Firoozi S and Ramezani S and Rahiminejad A and Karimi R and Farzaneh K and Mohseni M and Ghanbari H}, title = {Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process}, journal = {Materials Science and Engineering C}, volume = {69}, number = {}, pages = {1248-1255}, year = {2016} }
RIS	TY - JOUR AU - Rashti A AU - Yahyaei H AU - Firoozi S AU - Ramezani S AU - Rahiminejad A AU - Karimi R AU - Farzaneh K AU - Mohseni M AU - Ghanbari H TI - Development of Novel Biocompatible Hybrid Nanocomposites Based on Polyurethane-Silica Prepared by Sol Gel Process JO - Materials Science and Engineering C VL - 69 IS - SP - 1248 EP - 1255 PY - 2016 ER -

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