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Association Between Epstein-Bar Virus and Colorectal Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Jafari Maskouni E1 ; Jamalvandi T2 ; Tabatabaei F3 ; Bourenjan Shirazi S4 ; Saadati H5 ; Letafati A2 ; Hosseini M6 ; Motlaghzadeh S6 ; Khalesi Z2 ; Moradi P7 ; Saeb S8 ; Sheikh N8 ; Fozouni E1 ; Khatami A6 Show All Authors
Authors
  1. Jafari Maskouni E1
  2. Jamalvandi T2
  3. Tabatabaei F3
  4. Bourenjan Shirazi S4
  5. Saadati H5
  6. Letafati A2
  7. Hosseini M6
  8. Motlaghzadeh S6
  9. Khalesi Z2
  10. Moradi P7
  11. Saeb S8
  12. Sheikh N8
  13. Fozouni E1
  14. Khatami A6
  15. Baker AH9
  16. Keyvanlou Z7
  17. Tamrchi V10
  18. Tavakoli A11
  19. Ghorbani S6
Show Affiliations
Authors Affiliations
  1. 1. Department of Microbiology and Virology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Converting Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
  4. 4. Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
  6. 6. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Virology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran
  8. 8. Department of Virology, Lorestan University of Medical Sciences, Khorramabad, Iran
  9. 9. Department of Microbiology, Islamic Azad University of Qaemshahr Branch, Mazandaran, Iran
  10. 10. Department of Microbiology of Golestan University of Medical Sciences, Golesatn, Iran
  11. 11. Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

Source: Microbial Pathogenesis Published:2023


Abstract

Aim: This study aimed to investigate the prevalence and any potential association between Epstein-Barr virus (EBV) infection and colorectal cancer (CRC). Methods: A systematic literature search was performed by finding relevant cross-sectional and case-control studies from main online databases. Heterogeneity, odds ratio (OR), and corresponding 95% confidence interval (CI) were applied to all studies through meta-analysis and forest plots. The analysis was performed using STATA Software v.14.1. Results: Twenty-three articles were included in the meta-analysis, eight of them were case/control and 15 were cross-sectional. The pooled prevalence of EBV among 1954 CRC patients was 18% (95% CI: 12%–26%; I2 = 93.14%). Furthermore, in geographical regions, the highest and lowest prevalence of EBV was observed in South America 30% (95% CI: 18%–43%) and Africa 0% (95% CI: 0%–5%), respectively. An association was found between EBV infection and CRC [OR = 3.4 (95% CI (1.13–10.27); I2 = 72.3%)]. Conclusion: EBV infection is associated with CRC and can be considered a potential risk factor for the development of CRC. Although the exact molecular mechanism of EBV infection in the development of CRC is still unknown, it seems that latent infection by EBV, intestinal damage, and inflammation can be important factors in the induction of CRC. © 2023
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